Absorption

Question 1

Oral absorption of a lipophilic drug (log P= > 2 will have?

Answer 1

• delayed and limited absorption

Question 2

more soluble = less permeable

Answer 2

• hydrophilic (ionized)

Question 3

_______ is the first event that determines the clinical efficacy and availability of a drug

Answer 3

• route of application

Question 4

The _______ determines the plasma-concentration time curve

Answer 4

• injection site

Question 5

What is the bioavailability for IV administration?

Answer 5

• 100%

- <100% for all other routes

Question 6

Oral absorption of a hydrophilic (log P= -2) will have?

Answer 6

• poor absorption

Question 7

Requirement for oral absorption to occur

Answer 7

• must dissolve in the aqueous boundary layer (ABL) to be able to be absorbed

Question 8

What is more likely to be absorbed a ionized drug or an unionized drug?

Answer 8

• unionized drug

Question 9

The passage of a drug from its site of administration into the plasma

Answer 9

• absorption

Question 10

What factors influence the plasma-concentration time cruve?

Answer 10

• blood perfusion levels
• > where blood perfusion is high we see high absorption
• > where blood perfusion is low, we see low absorption

Question 11

Oral absorption of a hydrophilic and lipophilic drug (log P=0) will have?

Answer 11

• good absorption

Question 12

If a weak base is placed in an acidic environment what will occur?

Answer 12

• the drug will ionize and it will not be readily absorbed

Question 13

Less soluble = more permeable

Answer 13

• lipophilic/hydrophobic (Un-ionized)

Question 14

The proportion of the administered dose that reaches the central compartment or plasma is ______

Answer 14

• bioavailability