Disorders of the Musculoskeletal System (Muscle disorders & PNS)

Question 1

0-12 year old boys, autosomal recessive, severe-FATAL, PSEUDOHYPERTROPHY of calf muscles, increased CPK 300 times. “X-Linked” Mother to son, Pelvis & Legs. GOWER sign.

Answer 1

Erb-Duchenn’s Muscular Dystrophy

Question 2

10-70 year old, autosomal recessive, mild, Less severe than Duchenne’s , slower, Pelvis and Legs

Answer 2

Becker Muscular Dystrophy

Question 3

10-20 year old, Autosomal Dominant, Mild, affect face and shoulders.

Answer 3

Fascioscapulohumeral Dystrophy

Question 4

Adults, autosomal dominant, slow progression, affects face, tongue and extremities

Answer 4

Myotonic Dystrophy

Question 5

Acute Polyneuropathy, Polyradiculitis, following surgery or immunization, ASCENDING paralysis. TYPE IV hypersensitivity. “Rubbery Legs”

Answer 5

Guillian-Barre aka Acute Demyelinating Polyneuritis aka Landry’s Paralysis

Question 6

What is the aka for Guillian-Barre?

Answer 6

Acute Demyelinating Polyneuritis aka Landry’s Paralysis

Question 7

Female, myoneural junction, decrease ACH receptors**, especially the cranial nerves, ptosis, diplopia, EYES affected first. TYPE II hypersensitivity

Answer 7

Myasthenia Gravis aka Erb- Goldflam’s

Question 8

What is the aka for Myasthenia Gravis?

Answer 8

Erb- Goldflam’s

Question 9

Common with small cell carcinoma (lung), Increased contractions with repeated stimuli. Autoantibodies inhibit presynaptic calcium channels, OPPOSITE of Myasthenia Gravis

Answer 9

Lambert-Eaton

Question 10

Autosomal dominant, Onset in childhood, CALF MUSCLE atrophy, demyelination, Pain

Answer 10

Charcot- Marie- Tooth

Question 11

Autosomal dominant, hyperextensible skin & joints, large artery FRAGILITY. Defective collagen

Answer 11

Ehlers-Danlos Syndrome

Question 12

30-40 year old, myalgia, early fatigue, painful cramps, weakness of exercising muscles

Answer 12

McArdle’s