Disorders of the Blood Vessels, Heart and Lungs Flashcards
What is the trifecta (3 risk factors) of Cardiovascular Disease?
smoking, high blood pressure, high cholesterol
What is Cardiovascular Disease related to?
the formation of plaque.
-collection of lipids inside arteries
Stable form of plaques
don’t cause major complications (unless it blocks an artery at this point)
Vulnerable Plaques
- unstable plaque
- thin covering, rupture, formation of thrombus, can lead to embolism
What is the difference between a thrombus and an embolism?
thrombus-blood clot
embolism - lodging of embolus in a narrowed artery
What is atherosclerosis?
literally translates to “hardening of the arteries”
usually a result of progressive thickening of arterial walls due to accumulation of fatty deposits
How does atherosclerosis happen? (steps)
- damage to the artery: inflammatory [most of the time, could be other stuff] response
- monocytes engulf LDL cholesterol: formation of FOAM CELLS and FATTY STREAKS
- formation of plaque: accumulation of fat along the inner walls of the arteries
- accumulation of calcium : crystallization of fat and cholesterol, artery stiffens
What are the main causes of atherosclerosis?
shear stress, high LDL, smoking, diabetes, abdominal obesity, low intakes of vitamins, aging
How does diabetes lead to atherosclerosis?
diabetes damages blood vessels which starts the inflammatory response
Explain why monocytes engulf LDL cholesterol (in the formation of atherosclerosis)?
monocytes tries to heal inflammation so it engulfs LDL to thicken the artery (it will retain in the arterial walls)
What determines if a plaque is stable or unstable?
the thickness of the covering
What is the recommended diet for atherosclerosis?
low fat, low Na, low alcohol
Why is LDL/VLDL called bad cholesterol?
Oxidized LDL is what is attributed to fat accumulation.
LDL is mainly fat.
Fat always gets oxidized.. you cant prevent this
Why is HDL called good cholesterol?
findings show that the consumption of HDL can help clear fatty accumulation from arteries…. HDL is able to penetrate the fatty streaks and clear it from the blood
will not completely clear up fat accumulation
What is Hypertension?
high blood pressure: 140/90 (consistently this high)
Primary or Essential Hypertension
- cause is unknown
- 90-95% of cases
- HTN without another disease