Diabetes & Hypo glycermia Flashcards
What is PKU?
Phenylketonuria.
Genetic disability to break down Phenylalanine (an essential amino acid)
seen in infants (if not diagnosed early will lead to death)
What are the S/S of PKU?
Skin rash
(3-6 months) irritability, franticness, sleeplessness
(1 y/o) irreversible brain damage
What is the treatment for infants diagnosed with PKU?
Strict diet while young. Low Phe. Formula (phenylalanine is an essential amino acid and almost impossible for you to eliminate Phe. entirely b/c it’s in a lot of food). Usually diet becomes less strict with age and most PKU babies are able to live normally w/o watching everything they eat
What is Galactosemia?
genetic inability to convert galactose into glucose.
Diet restriction: Milk
What are the complications of Galactosemia?
vomiting, diarrhea, liver enlargement, nervous system damage, coma, death
Galactose is in ________ found in _____ milk.
Lactose. Cow.
What is Diabetes Mellitus characterized by?
elevated blood glucose concentrations, disordered insulin metabolism, inability to secrete sufficient insulin, use insulin effectively, or both
Type 1 and Type 2
Which is the most common type of DM?
Type 2
What is IDDM?
Insulin Dependent DM - Type 1
produces little or no insulin: AUTOIMMUNE destruction of pancreatic beta cells
occurs in young people
SEVERE symptoms
What is NIDDM?
Non Insulin Dependent DM - Type 2
Overweight people over 40, obese kids can develop this
moderate symptoms
Can Type 2 diabetes lead to Type 1?
yes
What are the acute complications of Diabetes?
Hyperglycemia
Glycosuria
Diabetic Ketoacidosis
Hypoglycemia
What is Hyperglycemia?
high blood glucose
can cause damage to the blood vessels, nerves, and tissues
S/S
thirst, fatigue, acetone breath, labored breathing, hunger, blurry vision, increased urination
What is Glycosuria?
glucose in the urine.
-plasma glucose concentration exceeds renal threshold, passes to urine
Glucose draws additional water leading to POLYURIA (excessive urination) and POLYDIPSIA (excessive thirst)
What is Diabetic Ketoacidosis?
increased activity of glucagon.
- breakdown of triglyceride and protein
- fatty acid oxidation and gluconeogenesis (gluconeogenesis further increased blood glucose)
- excessive amount of ketones (acid) in the blood, low pH (ketoacidosis), spill into the urine (ketonuria - presence of ketones in the blood)