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Pathology II > Diseases of Bone - BFOL > Flashcards

Diseases of Bone - BFOL Flashcards

1
Q

describe the benign fibro osseous lesion

A
  • altered condition of bone
  • normal bone replaced
  • proliferation of fibrous connective tisuse
  • new mineralized component
  • developmental lesions
  • reactive or dysplastic processes
  • neoplasms
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2
Q

what are the 3 benign fibro osseous lesions

A
  • fibrous dysplasia
  • osseous dysplasia
  • ossifying fibroma
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3
Q

what are the 3 types of osseous dysplasia

A
  • periapical cemento osseous dysplasia
  • florid cemento osseous dysplasia
  • focal cemento osseous dysplasia
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4
Q

what are the 2 types of fibrous dysplasia

A

monostotic
- polyostotic

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5
Q

describe monostotic fibrous dysplasia

A
  • common
  • craniofacial
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6
Q

what are the two types of polyostotic fibrous dysplasia and describe each

A
  • mcCune albright sydrome: severe, bone, skin and endocrine lesions
  • Jaffe- Lichetenstein syndrome: mild, bone and skin lesions only
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7
Q

how does fibrous dysplasia appear on radiographs

A
  • ground glass appearance
  • shepards hook femur bone
  • expansion of bone
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8
Q

what are the histology features of fibrous dysplasia

A

looks like chinese characters

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9
Q

what is the gene involved in fibrous dysplasia

A
  • postzygotic GNAS 1 mutation- codes for a g protein and results in hyperfunction of cells in the involved tissues
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10
Q

the clinical severity of fibrous dysplasia depends on:

A

the point in time the mutation occurs

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11
Q

what cells and features are involved with early embryonic life in undifferentiated stem cell fibrous dysplasia

A
  • osteoblasts: multiple bone lesions
  • melanocytes: cutaneous pigmentation
  • endocrine cells: endocrine distrubances
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12
Q

what cells and features are involved in later emryonic life in skeletal progenitor cell fibrous dysplasia

A
  • osteoblasts
  • multiple bone lesions, cutaneous pigmentation
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13
Q

what are the cells and features involved in postnatal life fibrous dysplasia

A
  • osteoblasts
  • single bone lesion
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14
Q

describe cemento osseous dysplasia

A
  • benign fibro osseous process
  • abnormal reaction of bone
  • the most common benign fibro osseous lesion of the jaws
  • probably arises from elements of the PDL
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15
Q

describe periapical cemento osseous dysplasia

A
  • a benign fibro osseous lesion located in the periapical region of the anterior mandible
  • females 10:1
  • blacks 70%
  • ages 30-50 years
  • aasymtpmatic associated with vital teeth
  • solitary or multiple
  • early lesions lucent
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16
Q

what are the radiographic stages of periapical cemento osseous dysplasia

A

RL (osteoclastic stage) -> mixed -> RO (osteoblastic stage)

17
Q

are the teeth in periapical cemento osseous dysplasia vital

A

yes

18
Q

what is seen in the histo of PA cemento osseous dysplasia

A

bone and fibrous CT

19
Q

describe florid cemento osseous dysplasia

A
  • middle aged adults, strong racial predominance for african americans, strong female gender predominance
  • multifocal involvement, often bilateral and symmetric four quadrant involvement not unusual
  • lucent - mixed - opaque with thin peripheral RL rim
  • usually asymptomatic, possiblly dull pain, expansion rare
  • associated with simple bone cysts
20
Q

what is the predilection for focal cemento osseous dysplasia

A
  • middle aged adults mean 38 years
  • strong female gender predominance
  • possible racial predominance but not really
  • posterior mandible commonly
  • frequently in extractio nsite
  • thin peripheral radiolucent rim
21
Q

describe the cemento ossifying fibroma and its predilection

A
  • benign neoplasm
  • age 20-40 years old
  • female predilection
  • molar and pre molar region of mandible most common
  • radiolucent to mixed
  • expansion may displace teeth
  • may arise from elements of the periodontal ligement
22
Q

what is the biopsy feature of cemento ossifying fibroma

A

all comes out in one piece

23
Q

what is the histo for cemento ossifying fibroma

A

fibrous CT and bone

24
Q

how should you differentiate ossifying fibroma and fibrous dysplasia since both histo look the same

A

clinical and radiographic dx

25
Q
A

Pathology II (19 decks)

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