digestion - lecture 2 Flashcards
what are target cells for excitatory and inhibitory enteric neurons
smooth muscle cell or secretory cell
describe ans modulation of ens
cns = parasym (excitatory - vagal nerve ach onto nicotinic receptors) and symp (inhibitory release noradrenaline)
sensory afferent fibers to cns = send info to cns to activate and ans = feedback on system
describe activation of ans
Sensory afferents –> parasym = medulla pregang and ans efferents have effect
sensory afferents –> sympa = spinal chord postgang - sympathetic chain of ganglia
efferent sends through vagal nerve
describe things that effect cns
afferent neurons with info from chemoreceptors, osomoreceptors and mechanoreceptors
sight, smell and taste of foods = activates directly salivation and also secretion in stomach
emotional state = if anxious = not induce saliva as usual
also cortical pathways
happens outside gut wall = efferent autonomic neuron’s synapse on enteric neurons
what doe ans modulation of ens allow for
integrated activity over longer distances along git
long extrinsic reflexes
ps = excites - can excite inhibitory neurons
s = inhibits - can inhibit inhibitory neurons
what is neural control of integration by
ens and ans
what are non git hormones
may influence growth and development of git
what are git hormones
may influence activities outside git
what do git hormones do
regulates activities inside git
describe hypothalamic feeding center - stimulates hunger
increase appetite
ghrelin released by glands in stomach during fasting
describe hypothalamic feeding center - induces satiety
decrease appetite
leptin released by fat cells with overeating
what is des
diffuse endocrine system
scattered among other cells in mucosa
largest most diverse endocrine system in body
name 5 most important gi hormones
gastrin
cck
secretin
gip
vip
name 3 modes of hormonal reg and describe briefly
autocrine = own cell
paracrine = on nearby cell
endocrine = through blood stream capillary and the effects target tissues
what type of hormones are git regulatory hormones
mostly peptides
describe how git hormones get to target cell
released from mucosa inton portal blood (hepatic portal vein) and goes to liver then to heart then to systemic circ and then to target tissues (tissues of gut)
do git hormone have only one target
nooooooooo
multiple targets = diff effects like inhibitory or excitatory