Digestion and Metabolism (Ch. 41) Study Guide- Human Digestion: Flashcards
What is the order of the structures of the digestive system in humans?
a. Mouth/Oral Cavity:
- Teeth
b. Salivary glands
c. Pharynx
d. Esophagus
e. Stomach
f. Small Intestine
g. Pancreas
h. Liver
i. Colon
j. Control of Digestion - nerves and hormones
What digestion occurs in the mouth and how?
Teeth- tears and crushes food into smaller pieces to start digestion process.
Salivary glands- 3 pairs of glands in mouth secrete 1/2 ml/min when no food is present. Nervous stimulation of the glands increses release of salive (salt, water, mucus, urea and an enzyme amylase. Amylase breaks down starch into disaccharides (maltose). Saliva is basic and helps neutralize the acids produced by bacteria.
Pharynx- back of mouth contains lymphatic tissues- tonsils and adenoids. If these become chronically inflamed they may need to be removed. As we swallow food passes through pharynz to esophagus. A flap of tissue folds down- Epiglottis- to cover the openinf to the trachea so food doesn’t go down the “wrong pipe”.
Discuss the # and type of human teeth::
Humans have a combination of both sharp in front and flatter in back. Present in the upper and lower jaws with 32 teeth total and 20 of which are deciduous (milk) and are replaced during childhood:
Teeth of upper and lower jaws-
Front (4)- Incisors- chisel like for tearing
Cuspids (2)- canines - one on each side of incisors. Pointed and used for tearing.
Premolars (4) bicuspids- two on each side of cuspids. Float with sharp ridges for grinding.
Molars (6) tricuspids- three on each side behind premolars. Flat with sharp ridges for grinding. The last molar on each side are the “wisdom teeth” which are no longer useful and can cause problems for space and misalignment or abscess.
What are some problems for human teeth:
Smaller jaw from evolution forces problem with “wisdom teeth” molars- they can push up at odd angles and become “impacted” causing: abscess (infection under the gum line) , root erosion, misalignment of teeth and jaw bone, jaw fracture.
Cavity- bacteria feeds on food between teeth. They produce an acid waste that breks down the tooth’s enamel. They can stick to the teeth because of their peptidoglycon outer coating.
Crown- cusp (point or ridge) of tooth breks off. The dentist grinds down top of tooth and replaces it with porcelain or gold “cast” or crown.
Cap- crown on front teeth.
What is the function of liver bile:
The liver releases bile through the bile duct into the duodenum. Bile emulsifies lipids (coats fats breaking them into small droplets and mixes with water) so they can be digested.
Bile is stored in the gall bladder and released when lipids are in duodenum.
Discuss how the liver regulates the contents of the blood:
The liver regulates the contents of the blood by:
- Metabolizing (breaking down) alcohol, drugs and rendering it harmless (in small quantities) and makes Toxins, pesticides, carcinogens and some poisons less toxic. Also the normal steroid hormones that aid in muscle production and repair are metabolized.
- Producing most of the blood clotting proteins. The liver produces serum albumins (proteins) that can be added to the blood or taken out to regulate water levels preventing Edema (water build up in tissues). Blood ecomes hpotonic to tissue cells.
The colon: Discuss the function of the large intestine:
The main function of the colon is to absorb water from feces and reabsorb salt.
Some bacterial breakdown of cellulose occurs.
Feces is compacted and stored.
Some manufacture of vitamins by bacteria (ex. vitamin k- clots blood.
Neural and hormonal control of digestion:
Discuss the role played by the hormone:
Gastrin-
hormone released by stomach when protein is present. it causes release of HCL and pepsinogen as pH drops.
Neural and hormonal control of degestion:
Discuss the role played by the hormone:
Gastric inhibitory peptide (GIP)
Prevents movement of chyme from stomach to duodenum until duodenum is empty. Fat in chyme causes release of GIP.
Neural and hormonal control of digestion:
Discuss the role played by:
cholecystokinin
Stimulates contaction of gall bladder and release of liver bile into the duodenum. Triggered by fat in duodenum.
Neural and hormonal control of digestionL
Discuss the role played by the hormone:
secretin-
Stimulates release of bicarbonate ion by pancreas. Triggered by acidity in chyme in duodenum.
Symbiosis and vertebrate digestion:
Discuss symbiosis in the vertebrate digestive system:
Because vertebrates do not produce enzymes that hydolyze cellulose they need to house large populations of symbiotic bacteria and protists in fermentation chambers in their alimentary canals.
These microorganizms do have enzymes that can digest cellulose to simple sugars and other compounds that the animal can absorb.
In many cases the microorganizms also use sugars from digested cellulose along with minerals to make a variety of nutrients essential to the animal, such as vitamins and amino acids.
Metabolism:
Discuss the basal metabolic rate and obesity:
Basil metabolic rate is the energy used to maintain homeostasis. Mammals and birds are endothermic, (warmed mostly by heat generated by metabolism and their body temp is maintained within. In contrast fish, amphibians and reptiles are ectothermic - they gain their heat from external sources) which affects the basal metabolic rate but other items like body size and activity affect the rate.
Hormones affect metabolic rate too. Weight-regulating hormones are polypetides (proteins). These are:
Insulin- which causes liver and muscle cells to absorb glucose and stre it as a starch called glycogen
Glucagon- causes break down of glycogen and release of glucose.
Obesity occurs when hormones chnge. Appetite-regulating hormones are secreted by various organs and the brain.
Leptin suppresses appetite as its level increases. When body fat decreases, leptin levels fall, and appetite increases.
Ghrelin is an appetite stimulant secreted y the stomach wall and is one of the signals that triggers feelings of hunger as mealtimes approach.
The hormone PYY secreted by the small intestine after meals acts as an appetite suppressant that counters the appetite stimulant ghrelin.
A rise in blood sugar level after a meal stimulates the pancreas to secrete insulin which suppresses appetite by acting on the brain.
Metabolism:
Discuss leptin:
Leptin suppresses appetite as its level increases. When body fat decreases, leptin levels fall, and appetite increases.
Most obese people have an abnormally high level of leptin which stimulates apetite and prevents weight loss.
Diseases of the Degestive Tract:
List and define 12 diseases:
Cavity- bacteria feed on food between teeth producing an acid wast that breaks down the tooth’s enamal. They can stick to the teeth because of their peptidoglycon outer coating.
Abscess- in the mouth caused by localized infection under the gum line caused by molars root erosion.
Impacted wisom tooth- teeth grow in poorly, crooked due to overcrowded mouth/jaw. Causes infection and can lead to eroded and brocken jaw.
Pernicious anemia- related to incorrect polypeptide secretion by parietal cells in stomach. Causes Low B12 which is necessary for production of red blood cells.
Jaundice- bile “backs up” into blood and skin turns yellow.
Hepatitis- Viral infection of the liver. Usually accompanied by jaundice. Can be fatal.
Gall stones- Calcified Liver bile. Can block the bile duct.
Edema- Caused by bad functioning Liver. Water builds up in tissues due to lack of serum albumins (proteins produced by liver). Blood becomes hyopotonic to tissue cells.
Appendicitis- Associated with Colon. inflamed appendix. Bacteria produce todxins that eat away tissue.
Diarrhea- inflamed colon won’t absorb water from feces.
Hemorrhoids- In Colon, inflamed and swollen anal veins. May bleed. Painful.
Colostomy- An artificial exit from the colon created to divert waste through a hole in the colon and through the wall of the abdomen. A colostomy is commonly performed by severing the colon and then attaching the end leading to the stomach to the skin, through the wall of the abdomen. Usually a colostomy is performed because of infection, blockage, cancer, or in rare instances, severe trauma of the colon.
Esophagus
First tube that separates food from air. Connects pharynx to stomach. 10” long. Circular muscles contract- PERISTALISIS- and squeeze food along to a concentrated ring of circular muscle-sphincter-which can pinch down and prevent food. Spincters keep food in a part of the digestive until it has completed the necessary phase of digestion.
Stomach
Muscular sack that starts the break down of proteins into peptide chains:
- size increases to hold about a gallon (2-4 liters)- DISTENSION- expansion
- normally folded up like an accordian when empty (-50 milliliters). Can distend to allow for “gorging” by carnivores
- extra muscle layer allows stomach to “churn”
- stomach produces gastric juices:
a. hydrochloric acid (HCL) produced by secretory cell called a parietal cell. Lowers ph\H to 2. Low pH activates prtease enzyme. HCL helps denature (remove amino groups) proteins into smaller polypeptides. Stomach acid also kills most of the bacteria in the food we eat. Some bacteria can withstand the low pH and live in the small and large intestine.
b. pepsinogen- an enzyme is converted to pepsin (a more active form) in a low pH environment.
Food Chewed and swallowed into the stomach is called a BOLUS.
Food in the stomach and small intestine is called CHYME. Chyme stayes in stomach 2-4 hours.
The lining of the stomach is- the GASTRIC MUCOSA- which produces a basic mucus that protects the stomach from its own digestive juices.
An ULCER forms when production of too much acid for mucosa and the mucosa gets eaten away. Or under production of mucus to protect the stomach lining (Gastric mucosa). Gastric ulcer occurs in the stomach. Duodenal uslcer in first foot of small intestine (most ulcers (90%) are duodenal.
Water, alcohol and aspirin are about all that can be absorbed through stomach into blood.
Small Intestine
Final digestion and absorption occurs in the small intestine.
-18-22 feet (4.5 meter) long.
The first 1 foot is the DUODENUM. Most digestion occurs in the duodenum. Absorption occurs all alonf small intestine.
- The liver “dumps” bile into duodenum.
- The pancreas “dumps” digestive enzymes into the duodenum.
Small intestine - Duodenum 1-1.5 feet/ mostly digestion
Jejunum = 7 feet for absorption & digestion
Ileum = last 4 feet for absorption & didestion
Villi increase the surface area of the small intestine for greater absorption. Microvilli absorb nutrients and pass monsaccharides and amino acids into capillary network of villus.