Diabetic Complications Flashcards
Hormones
Regulate metabolic activity of an organ or tissue.
Insulin
Secreted by the pancreas, regulation of carbohydrate metabolism, active part in the metabolism of fat (hydroglycerides) and proteins.
Diabetes
Shortage of/ decreased ability to use insulin. When not controlled, glucose and fats remain in blood over time and cause damage to tissues/organs.
Secondary Pathologies of Diabetes
Heart Disease
Stroke
Blindness
Kidney Failure
Pregnancy Complications
LE amputations
Death related to flu/pneumonia
Secondary Pathologies of the Foot (Diabetes)
Diabetic Neuropathy
Peripheral Vascular Disease
Nail Conditions
Macerations/Infections
Pre-Ulcerative Callusing
Ulcerations
Charcot foot deformity
Amputations
Diabetic Neuropathy
Type I & II
Affects ~70% of people w/ diabetes
Destroys the axons/myelin
Damaged nerves do not transmit the proper signal
Loss of sensation/pain/hypersensation
Peripheral Neuropathy
Most common form of neuropathy
Numbness, tingling, burning, dull ache, stabbing pain/cramping
Skin sensitivity
Foot ulcers
Peripheral Vascular Disease
Similar to coronary artery disease
Fatty deposits build up in inner linings of artery walls
Cramping or fatigue in legs
Nail conditions
Toenails should be evaluated for infection / onychomycosis (thick yellow nails that are difficult to cut)
Ingrown toenails / onychomycosis can cause infection at nail border.
Maceration
Occurs between the toes and leads to infection.
Very dry skin w/ cracks.
Pre-Ulcerative Callusing
Body’s response to unnatural increased pressures on neuropathic foot.
Underlying skin can break down.
Ulcerations
Areas most subjected to weight bearing/stress
Most prominent on tips of the toes.
Charcot Foot Deformity
Sensory neuropathy involving feet.
Motor neuropathy - intrinsic muscle weakness, splaying of foot on weight bearing compounds trauma.
Convex foot with rocker bottom appearance.
Amputations
50% of all non-traumatic amputations.
Of these:
24% digit
5.8% midfoot
38% BK
21.2% AK
10% other sites
Type I Diabetes
5-10% of diagnosed cases
Formerly called: Juvenile diabetes or Insulin Dependent Diabetes Mellitus (IDDM)
Onset <25yrs
Immune system attacks and destroys its own insulin producing beta cells.