Diabetes Flashcards
what occurs in the body when you dont have diabetes?
- The food that is consumed, moves into the blood stream as glucose
- Insulin from the pancreas is released in response to the increase of glucose in the bloodstream. Insulin is the key for unlocking cell receptors and allowing glucose to move into the cells
Insulin
- A hormone that is secreated by the beta cells in the islet of langerhans
- secreted by the beta cells of the pancreas
- stimulus for insulin is high blood glucose levels
pre-diabetes
impaired glucose intolerance
* occurs when glucose levels are higher than normal, but not high enough for a diagnosis of diabetes
* high risk for developing type 2 diabetes & CV diease
Gestational diabetes
- occurs during pregnancy
- high risk women include= obese, advanced age,family history of diabetes
- increased risk for c-section, prenatal death, and fetal injury
- screening at 24-28 weeks using OGTT
- blood sugar returns to normal within 6 weeks postpartum
type 1 diabetes
- autoimmune disease
- insulin dependent
- genetic deposition
- more common in yong indiv
- 5-10% of all diabetes
- no or little insulin production
what occurs with type 1 diabetes
- the pancreas stops making insulin
- glucose builds up in the blood
- cells have no glucose for energy
- body breaks down fat and protein
- ketons are made
how do you manage type 1 diabetes
Replace insulin
1. background insulin
2. bolus insulin
type 2 diabetes
- most prevalent
- gradual onset
2 main problems
1. insulin resistance=body has decreases sensitivity to insulin
2. inpaired beta cells functioning, which results in decreased insulin production
Contriubuting problem
* muscles- making up glucose for energy effeciency; imparied insulin secretion
* Fat- altered production of hormones and cytokines by adipose tissue
Risk factors for diabetes
- family history of diabetes
- obesity
- BMI >27
- race/ethnicity
- HTN
- triglycerides > 200 mg/dl
- previous impaired glucose tolerance
clinical manifestations for diabetes
- polyuria
- polydipsia
- polyphagia
- weakness/fatigue
- dry mouth
- numbness in hands/feet
- high blood sugars
- dry itchy skin
- cellulites
- blurred vision
- high blood pressure
- weight loss or gain
Diagnostic studies
- A1C of 6.5% OR higher
- fasting plasma glucose level of > 126 mg/dl with no calorie intake for 8hr
- two hr OGTT level >200 mg/dl using a 75g glucose load
Tools for self measurment for diabetes
- medication
- good nutrition
- incresed physical activity
- monitoriting blood glucose
Drug therapy for diabetes
- drugs+nutrition+exercise= GOOD
- medication may need to increase as disease progresses
- injectables: insulin and noninsulin
- oral medications
insulin
3 major characteristics of insulin
1. onset
2. peak
3. duration of action
* can only be given subQ
* comes in a vial or pen device
* can be delivered by insulin pump
componets of insulin regimen
Basal insulin- background coverage
bolus insulin- mealtime coverage
correction- bolus insulin used to correct occasional high BG excursions
intensive insulin therapy is the use of both basal and bolus insulin consisting of multiple daily injections
long acting (basal) insulin
- keeps blood glucose levels consistant when not eating
- covers hepatic glucose production
- migrates dawn production
- characterized by hyperglycemia that is present on awakening in the morning due to the release of counter-regulatory hormones in the predawn hours