Devin • Baccillus Flashcards

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1
Q

Bacillus anthracis plasmid name?

A

plasmid pX01

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2
Q

plasmid pX01 of Bacillus anthracis codes for?

A
protective agent (PA), edema factor (EF) and lethal factor (LF)
o	PA + EF = edema toxin
o	PA + LF = lethal toxin
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3
Q

lethal factor (LF)

A

zing-dependent metalloprotease that cleaves MAP kinase, leading to inhibition of innate immunity, cell death, and release of inflammatory cytokines

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4
Q

lethal factor (LF)

A

calmodulin-dependent adenylate cyclase that increases cAMP

o results in edema and inhibition of innate immunity

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5
Q

Bacillus anthracis has a polypeptide capsule?

A

yes! polypeptide capsule – poly-D-glutamic acid

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6
Q

Bacillus anthracis plasmid pX02 carries what info?

A

carries capA, capB, and capC that synthesize the polypeptide capsule

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7
Q

Bacillus anthracis has a special stain for what?

A

spore stain (malachite green stain) used to visualize spores in specimens

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8
Q

Bacillus cereus heat-stable, proteolysis-resistant enterotoxin =

A

emetic form of disease (rice)

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9
Q

Bacillus cereus heat-labile enteroxin =

A

diarrheal form of disease

•induces adenylate cyclase activity

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10
Q

Bacillus cereus ocular infections have 3 toxins?

A
  • necrotic toxin – heat labile enterotoxin
  • cereolysin – potent hemolysin named after species
  • phospholipase C – potent lecithinase
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