Development B7

Question 1

As the optic cup folds in upon itself, the “back” of the cup comes into contact with the layer from the front of the cup. They come together to form this “_____________________” relationship.

Answer 1

apex to apex

Question 2

The small space left over by this process is initially called the ________________

Answer 2

Intraretinal space

Question 3

Inner and outer layers of retina

Answer 3

Posteriorly: 
-Outer layer: RPE
-Inner layer: Neural Retina
More Anteriorly: 
-Outer layer: pigmented ciliary epithelium
-Inner layer: Non-pigmented epithelium
Most anterior: Outer layer: anterior iris epithelium
Inner layer: posterior iris epithelium

Question 4

When is the earliest pigmetation evident in the embryo?

Answer 4

week 3 to 4

Question 5

After week __ the RPE is one cell thick.

Answer 5

6

Question 6

At approximately week __, a inner and outer neuroblastic layer is forming. Between these 2 is the transient fiber layer of chievitz

Answer 6

7

Question 7

Neural retina will subdivide into two distinct areas beginning around weeks ______

Answer 7

4 to 6

Question 8

________ cells migrate, forming a layer close to the basement membrane which becomes evident by week 8.

Answer 8

Ganglion

Question 9

_________ cells, located rather centrally in the inner neuroblastic layer, develop at the same time as ganglion cells.

Answer 9

Muller

Question 10

The bodies of the Muller and amacrine cells remain in the inner neuroblastic layer but move slightly ______.

Answer 10

sclerad

Question 11

By week 12 the ____________ are aligned along the outer side of the inner layer of the optic cup and.

Answer 11

photoreceptors

Question 12

Which photoreceptors develop first?

Answer 12

Cones develop first then rods second

Question 13

Adhering junctions form the precursor of the ___________________.

Answer 13

External limiting membrane

Question 14

The photoreceptor cells are the last cells of _________ to differentiate, occurs during the 5th month.

Answer 14

neural retina

Question 15

Where do Horizontal, Bipolar, Amacrine, and Muller cells develop at?

Answer 15

inner nuclear layer

inner and outer plexiform layers are filing with neuronal processes

Question 16

The fibers of the Muller cells appear and extend to the basal lamina, forming the primitive ___________________.

Answer 16

internal limiting membrane

Question 17

____________ cells provide a scaffolding for cell development and appears to be involved with guiding the direction of axonal fiber growth.

Answer 17

Muller

Question 18

What do plexiform layers consist of?

Answer 18

Synapses of axon

Question 19

WHat develop earlier? Rod spherules or cone pedicles?

Answer 19

Cone pedicles develop earlier

Question 20

What came before what?
Central or peripheral?
Cones or rods?
Inner or outer?

Answer 20

Central before peripheral
COnes before rods
Inner plexiform layer before outer layer
(Photoreceptor synapses with bipolar cells are eztablished before the outer segments are completed)

Question 21

By month 5 the ____________ layer is well established.

Answer 21

ganglion

Question 22

Since retinal development happens before peripheral, what is significant here?

Answer 22

By the time peripheral nerves got their axons in place they have to detour up and around the central, this line of deviation is termed the HORIZONTAL RAPHE

Question 23

By month 6 there is no further mitosis, and retinal growth continues because of cell _________, ________,and __________.

Answer 23

differentiation
growth
maturation

Question 24

Foveal depression continues to deepen until about age 15 months as cells continue to move toward the _______________.

Answer 24

macular periphery

Question 25

At birth there is still a single layer of ________ cells and a thin ________ layer across the now-depressed foveal area.

Answer 25

ganglion

inner nuclear