Dermatology - Rashes + Ulcers Flashcards
1
Q
Definition - Acanthosis Nigricans
A
Dry, dark patches of skin typically in the armpits, back and groin
A sign of an underlying condition
2
Q
Causes - Acanthosis Nigricans
A
Obesity
T2DM
Cushing’s
PCOS
Gastric cancer
3
Q
Presentation - Acanthosis Nigricans
A
Dark, thick, velvety patches of skin
Itch
4
Q
Diagnosis - Acanthosis Nigricans
A
Clinical diagnosis
Investigate for an underlying cause
5
Q
Management - Acanthosis Nigricans
A
Treat underlying cause
No cause = topical tretinoin
6
Q
Pathophysiology - Acanthosis Nigricans
A
- Insulin resistance
- Hyperinsulinaemia
- Stimulation of keratinocytes via IGFR 1
