Dermatology Flashcards
What are some allergy triggers?
Environmental allergens
Food
Ectoparasites
Contact allergens
Microorganisms
Drugs
What is canine atopic dermatitis?
Common, chronic, relapsing, pruritic and inflammatory skin syndrome with characteristic clinical features.
What are some common environmental allergens?
Dust mites, pollens and moulds
When does environmental canine atopic dermatitis occur?
On re-exposure of an allergen
What pathophysiology occurs on re-exposure to an allergen?
Degranulation of mast cells and production of cytokines from activated T-cells.
What are the 7 points of Favrot’s criteria for environmental CAD?
- Age of onset <3years
- Living mostly indoors
- Glucocorticoid-responsive pruritus
- Non-lesional pruritus
- Affected front feet and/pr pinnae
- Unaffected ear margins
- Unaffected dorsal/lumbar area
What are the clinical signs of uncomplicated environmental CAD?
Erythema, self-induced alopecia, excoriations, primary popular eruption
What common food sources can cause a food allergy in dogs?
Beef, dairy, chicken and wheat
What is feline atopic skin syndrome?
Inflammatory/pruritus skin syndrome likely associated with IgE
Pros and cons of using glucocorticoids for allergies
Pros: Highly effective for inflammation and pruritus, rapid onset (24hrs), inexpensive
Cons: Significant side effect risk
What is oclacitinib (apoquel) licenced for?
Dogs that are a minimum of 1 year old
What is the action of lokivetmab (cytopoint)?
Blocks interleukin-31
Pros and cons of lokivetmab?
Pros: Good safety profile, excellent anti-pruritic, rapid onset, use in dogs of any age, with impaired liver/kidney function and neoplasia
Cons: Dogs only, efficacy may be lost with time, minimal anti-inflammatory effect, rare anaphylaxis
What is ciclosporin licenced for?
Dogs and cats
What is the action of ciclosporin?
T-cell suppressor
What are the challenges with cat allergy management?
- Few licenced products
- Administration of treatments more difficult
- Vet visits more stressful
- Scratching can cause rapid and severe damage
What is the most common bacterial skin infection?
Staphylococcus pseudintermedius
What are signs of a bacterial skin infection?
Focal to multifocal patches of alopecia +/- pustules and crusts.
Most common species of ringworm
Microsporum canis
Indications for mild cases of ringworm
Scale and associated alopecia. Multifocal patches are often circular and typically 4-6cm +/- hyperpigmentation. Follicular casts.
Diagnostic options for ringworm
Woods lamp, trichography, in house DTM, external lab fungal culture +/- PCR
What causes demodicosis?
Demodex mites
Indications of juvenile onset demodicosis
Localised or generalised. Alopecia, scaling, blue-grey hyperpigmentation, comedones, follicular casts +/- superficial bacterial infection