Dermatitis Pt 2 Flashcards

1
Q

what is the first line treatment for contact dermatitis

A

TCS are first line treatment for localized ACD

  • use moisturizers as an adjunct, esp for chronic ACD
  • can use TCI as an alternative to TCS when ACD is unresponsive, invovles skin folds or when thought to be caused by topical corticosteroids
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2
Q

what is the first line treatment when large BSA or when the face, hands, feet or genitalia are involved and quick relief is desired

A

oral corticosteroids

prednisone

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3
Q

when ACD is unresposnive to topical or oral corticostoerids what do you do

A

use phototherapy

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4
Q

when would you use systemic therapy

A

rarely used in resistance cases of ACD

ex: cyclosporine azathiopine

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5
Q

what is the mainstay treatment for ICD

A

TCS and moisturizers

  • mostly based on empirical data -> TCI have not ven proven to be effective in ICD and not current recommended
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6
Q

what can be used to protect skin against irritants and occupational settings (ICD)

A

topical barrier products (containing silicone and/or zinc related compounds)

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7
Q

with of colloidal oatmeal

A

evidence is limtied

  • can be used in both allergic and ICD to reduce itch and soothe the skin
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8
Q

use of frist gen antihistamiesn for contact derm

A

avoid

maybe can be used to help with sleep i young healthy patients

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9
Q

use of moisturizers and soap in patients with stasis dermatitis

A

improve skin hydration and restore normal barrier function of the skin

mild soap or soapless cleanser should be used during bathing

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10
Q

first line to reduce inflammationa and itch during acure SD flares

A

TCS are frst line to reduce inflammation and itch during fales

  • but prolonged use of higher potency CS is not recommended due to risk of akin atrophy and consequently inc risk of ulceration

* use short course of systemic therapy with an oral corticosteroid like prednisone if not responsing to topical corticosteroid therapy

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11
Q
A
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12
Q

use of antibotics, TCI for SD

A
  • antibiotics (topical or systemic_ used when secondary bacterial infection is present
  • some evidence for use of TCI but not normally indicated
  • systemic therapy (pentoxifylline) bay be considered for treating underlying CVI when non pharm strategies are insufficient
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13
Q

non pharm treatments for atopic and contract dermatitis

A

* first like is avoding allergens and irritants

  • envirnment
    • home/work in temperate moderate humidity
  • Phyiscal activity
    • swimming may be tolerated bc less sweating and can remove allergens from skin & reduce colonization by staphylococcus aureus
    • despite drying swimming in chlorinated pools shown to help some atopic patients -> use gentle cleanser after
  • Clothing
    • loose fiting cotton or cotton blend
    • avoid occllusive clothing fabrics like nylon ro wool
    • avoid fabric softener, bleach or dryer sheets
    • use liquid detergent over powder
  • Personal hygiene
    • bathe in lukewarm water and mild soap or soapless cleanser
    • limit 5 min for shower and 15 for baths, abths generally preferred bc shown to rehydrate skin
    • pat dry w/ towel
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14
Q

wet dressings for treatment of atropic and contact derm

A

* non pharm method

  • Compress
    • when oozing and crusting present
    • cools and drys skin through evaporation
  • Soaks
    • when hardens crusts or scallign is present (chronic AD)
    • softends hardened crusts and hydrates the skin
  • Wraps
    • Moderate to severe AD and/or resistant cases
    • increases penetration of topical agents, dec water loss and provides a physical barrier against scratching
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15
Q

how to use a compress

A

Soak gauze or a thin cloth with room temperature solution

Wring gently so it remains wet, but not dripping

Apply to the skin, remove, remoisten and reapply every few minutes for 20-30 mins, 4-6x/day

May apply a lotion after, but avoid occluding with an ointment

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16
Q

how to use a soak

A

Saturate the gauze or cloth with solution

Apply to area for 15-20 mins without removal

17
Q

how to use a wrap

A

A topical agent is covered by a wetted layer of tubular bandages, gauze, or other material

A second dry layer is then applied

Wraps can be worn for several hours, depending on patient tolerance

18
Q

using compresses in stasis dermatitis

A
  • can use wet dressings as compresses or soaks, will cool and dry weeping skin through evaporation
  • soid applying non essential topical agents bc they are readily sensitized and at risk of developing CD

* esp ointment bases which tend to be irritating in SD

19
Q

non pharm measures for treatment of SD

A
  • treat underlying CVI
  • lifelong compression theapy needed -> gradient compression stockings
  • facillitates blood flow to heart, reduces capillary leakage itno tissue and supports lymphatic drainage of interstitial fluid
  • general rec is 20-40 mmHg
  • other non pharm strategies = daily walking or exercise, weight reduction, or ablation therapy.
20
Q

contraindications of compression therapy

A

peripheral artery disease,

severe peripheral neuropathy,

massive leg edema or pulmonary edema from congestive heart failure,

local skin or soft tissue conditions (e.g., a recent skin graft, severe cellulitis, gangrene),

allergy to stocking material,

or an extreme deformity of the leg that would prevent proper stocking fit.

22
Q

NHP for treatment of atopic dermatitis

A
  • little evidence
  • probiotics durin preg or breastfeeding may prevent AD in child
  • evening primrose oil and borage oil are widely used but clinically unsubstantiated
  • traditional chinese medicines have been sued for years but safety and efficaccy not well stuided in clincial treils
  • acupuncture or massage therapy may improve sigsn and sympoms but studies have been small and of limited quality
23
Q

NHP for contact derm

A

few studies

  • soem evidence that oral admin of sinc sulfate may imporve ACD due to nikle sensitivity
24
Q

NHP for stasis dermatitis

A
  • micronized purified flavonoid fraction (MPFF), a mix of diosmin an hesperidin can be useful ad adjunct to compression therapy to impove small ulcer healing, edema, trophic changes of the skin, and subjective symptoms of CVI
  • NPFF associated with few side effects, so given the potential gbenefits and favourable safety can consider for management of underlying CVI in patients with CD
25
product selection guidelines for dermatitis in children and older adults
- systemic abs of TCS is increased due to hgiher sin surface area to boy weight ratio and age related skin changes respectively - use lowest potency topical corticotoerid that is effectie for shortest duration possible - risk of hypothalamic pituitary adrenal axis suppression and other stoerid related side effects greater in these pop
26
product selection considerations for dermatitis in pregnant/breastfeeding
- used lowest potency TCS for shortest duration possibe - systemic abs of TCS is low and use is reported to pose no risk to baby when used in preg, and unlieky it would be passed on via breastmilk - TCI are also poorly abs folloing topical admin so can consider in second line therapy - if topical corticosteroid or calcineurin inhibitor is applied to the breast, remove before feeding - safety of crisaborole ointment has not been evaluated in human pregnancy - phototherapy and UV is fine - systemic therapy with agents like methotrexate is generally contraindicated
27
what clinical pearls are associated with topical corticosteroids
"corticophobia" negative feelings and beliefs related to TCS use - results in poor adherence and treatment - only apply CTS to intact skin - avoid occluding the treated areas unless directed to do so by HCP - seek reassessment for skin lesions that do not improve after 2 weeks of therapy
28
pros and cons for topical agents
* Lotion * pro: less greasy and good for large or hairy areas * con: alc based, hgiher water content * Cream * Pro: cosmetically accetable, good or weeping areas * cons: less abs * Ointment * Por: excellent penetration, emollient effects, good for dry scaly skin, less irritating * Cond: less cosmetically acceptable, may cause skin irritation in hot humid env
29
how much FTU to apply to Face & neck Trunk, front and back arm and hand leg and foot
Face & neck: 2.5 FTU Trunk, front and back: 14 FTU arm and hand: 4 FTU leg and foot: 8 FTU
30
monitoring and follow up for inflammation and pruritis area involved sleep and/or daily activities adverse effects of therapy
inflammation and pruritis: dec by 50% in 7-10 days area involved: no progression sleep and/or daily activities: may take several weeks to return to normal adverse effects of therapy: none/minimal \*patient monitor daily, RPh in 7 days for acute cases