Derm Drugs

Question 1

Keri oil and aveno bath preps for dermatitis treatmetn

Answer 1

• Keri oil (bath oil)
  
  • slows water loss fomr skin, improves xerosis and soothes irritated skin
  • add to bath water near end of abthing (if add earleir wil prevent hydration bc it coats the skin)
• Aveno (colloidal oatmeal)
  
  • decreases pruritis
  • add to bathwayer

Question 2

moisturizers for treamtnet of derm

Answer 2

• Glaxal base or lubriderm (emmolients)
  
  • slow water loss and lubricate skin
  • oil in water products will dec pruritis
  • apply thoughot day PRN (at least TID), best used after bathing
• Dermal therapy, Neostrata (hydrating therapy)
  
  • decrease water loss from skin
  • apply same as emolients: PRN at min TID
    
    • *alpha hydroxy acids can cause irritation if conc >105
• Compelx 15 or Barriere (occlusive agents)
  
  • delay water evap from skin and protect form irritants
  • PRN app several times daily
• Cetaphil, restoraderm (barrier repair products)
  
  • resote ceramine balance in skin
  • apply thin layer BID or PRN

Question 3

OTC topical corticosteroids for dermatitis

Answer 3

Hydrocortisone 0.5, 1% (Cortate cream)

Clobetasone butyrate (0.05%), spectro eczema care

• dec inflammation and pruritis
• apply BID to TID for max 2 weeks

*hydrocort 0.1-1% is considered a NHP, clobetasone is schedule II and not rec <12

• May cause stretch marks, spider veins, and atrophy
• Risk of HPA axis suppression

Question 4

where to use lowest and highest potency topical corticosteroids

Answer 4

• lowest potency: face (hydrocort 2.5%)

lower-medium: abdomen (hydrocort valerate 0.2%)

high potency: feet (betamethasone dipropionate)

Question 5

Rx agent to treat mild dermatitis

Answer 5

• hydrocotrisone 2.5% cream (lowest potency)
• Desonide 0.05% cream (low potentcy)

Question 6

Rx topical corticosteroids to treat moderate derm

Answer 6

• Medium potency:
  
  • Betamethasone valerate 0.05%, 0.1% (cream, ointment, lotion)
  • Mometasone furoate 0.1% (cream, lotion)
• Hihg potency
  
  • Betamethasone dipropionate 0.05% (cream, lotion)
  • Fluocinonide 0.05% (cream, ointment)

Question 7

Rx topical corticosteroids to treat severe derm

Answer 7

• very high potency
  
  • Clobetasol propionate 0.05% (cream, topical solution)
  • Halobetasol propionate 0.05% (cream, ointment)

Question 8

what topical calcineurin inhibitors are available to treat derm, what is their mech, instructiona dn cautions

Answer 8

• Pimecrolimus 1% cream (Elidel®)
  
  • mild to moderate AD
  • do not use <3 months
• Tacrolimus 0.03%, 0.1% ointment (Protopic®)
  
  • moderate to severe
  • do not use <2 for 0.03, 0.1 reserved for >16
• Mechanism (both)
  
  • Cyclosporine analogue with antiinflammatory effects
• Instructions for use
  
  • apply BID
  • sometimes 2-3x weekly for plate prone areas to prevent recurrence
• comments
  
  • contraindicated in immunocompromised
  • can cause transient burning
  • alc ing can cause redness and during
  • avoid unnecessary UV exposure

Question 9

what topical PDE-4 inhibitors are available to treat derm, what is their mech, instructiona dn cautions

Answer 9

Crisaborole 2% ointment (Eucrisa®)

• treats mild to moderate AD
• boron based mol that blocks PDE-
• applied BID

*not indicared for children <3 months

• may cause stinging or burning

Question 10

antihistmaines for treatment of derm

Answer 10

• First gen (diphenhydramine)
  
  • cna ipmrove sleep and may dec itching
  • dosing is product specific, give give near bedtime
• Second gen
  
  • Fexofenadine (Allegra®) Loratadine (Claritin®) Desloratadine (Aerius®) Cetirizine (Reactine®)
  • may help with coexisting symp of allergic rhinitis
  • fexofenadine may decrease itch
  • dosing is product specific

* not rec as sub for better disease conctol

*topical antihis not recommended