Dandrugg and seborrheic dermatitis Flashcards

1
Q

what is dandruff and seborrheic dermatitis

A
  • Dandruff (pityriasis simplex capitis) and seborrheic dermatitis (SD) are papulosquamous cutaneous disorders​
  • both cause scaling associated with itching
  • dandrugg is a milder non inflammatroy form of SD and is limited to scalp
  • SD is an inflammatroy condition with erythematous and scaling eruptions in “seborrheic areas” (scalp, face and upper trunk)

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2
Q

who is most often affected by dandruff and SD

A
  • Dandruff usually begins 10-20 and efefcts up to 50% of indivduals over 30
  • SD is found in 1-5% of population, 30-33% of immunocompromised patietns and 83% of HIV
  • Sd is most common in first 3 months of life and between 30-50
  • affects more amles -> androgens affect secaceous galnd activity
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3
Q

development of SD

A
  • controversy over cuase
  • some say that fungal disease, others say fungal disease is secondary to the primary inflammatroy dermatosis that results in icnreased cell turnover, scalling and inflammation in epidermis

*means that treatments vary ranging from topical antifungals to topical corticosteroids and calcineuin inhibitors

*no direct relationship between amount od sebum and condiiton

*suggested response to materanl androgen stimulation

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4
Q

what are the goals of therapy for dandruff

A

Reduce or eliminate scales (dry flakes of skin) and flaking

Prevent recurrence by improving scalp hygiene

Eliminate or reduce environmental triggers

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5
Q

goals of therapy for seborrheic dermatitis

A

Control not cure

Reduce fungus and the resulting scaling and inflammation

Relieve symptoms such as pruritus

Educate on the importance of control through good hygiene

Eliminate or reduce environmental triggers

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6
Q

what to assess for in patients

A

Onset, frequency and duration of symptoms

Area and extent of involvement

Description of skin lesions

Associated systemic symptoms

Aggravating factors

Current hygiene practices

Attempted treatments

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7
Q

what are the symptoms of dandrugg and seborrheic dermatitis

A
  • lesions of SD and dandrug are often asymptomatic
  • variations in intensity of episodes can be precipitated by fature, stress or cold weather
  • dandruff is usually asymptomatic, although itching amy develop
  • in SD puritus varies, being common in scalp and ear canal involvement and can be intense
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8
Q

what are the sings of dandruff

A
  • shedding of small fales from scalp showign minimal erythema with limited or no inflammation
  • scales are silver-grey in patches or diffuse and may separate fully or become detached after combind
  • no evidence of skin disease on scalp or elsewhere
  • oftne confused with SD, tinea capitis and psoriasis
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9
Q

what is SD charcterized by

A

sharply demarcated yellow to brown, greasy or bran-like scaling patches and plaques.

  • typically affects symmetic areas of skin rich in secaceous glands (hary areas of scalp, scalp margin, eyelashes, browns, beard and mustache)
  • ca also affect nasolabial folds, forehead, outer ear canals and in the creases behind the ears
  • can happen on torso
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10
Q

progression of SD

A
  • begins in small patches, rapidly spreading, with diffuse fine scales that can be white, off-white or yellow with no signs of acute dermatitis such as oozing or weeping
  • Exudation may be seen in facial SD from time to time.

* can rpesent diff in indivual with dark coloured skin, appearing scaly hypopigmented macules and patches in typical areas of involvement

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11
Q

patterns to SD flares

A

resolves in a cyclic or seasonal fashion, often in response to stress.

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12
Q

effect of SD on eyes

A
  • profuse powdery scales on eyeborwns and compromize wearing of contact lenses
  • eyelides alone can be affected, developing blepharitis
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13
Q

paranasla involement of SD

A

typically seen in young women who may not have dandruff.

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14
Q

most common type fo facial SD in males

A

upper lip, beard, scalp, back, flanks and abdomen.

Plaques may present with thick, adherent silvery scales (as seen with psoriasis), which usually spare the face, called sebopsoriasis.

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15
Q

SD in infants

A

entire scalp may be covered with thick, dry adherent, yellowish brown scalres overlying erythema

  • called ‘cradle cap”
  • can also invovle central face, forehard and ears

*self limting, appears in first to fourth week fo life and usually disappears in 3 months

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16
Q

diagnosing SD

A

must be distinguished from dandruff and psoriasis

as well as tinea capitis, atopic dermatitis, rosacea, systemic lupus erythematosus and fungal skin infections.

*refer when diagnosis is uncertain or failure to respond to first line treatment after 4 weeks

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17
Q

what factors aggredate SD

A
  • gnertic predisposion
  • HIV positing or AIDS
  • neurologi condition like parkinsons

being middle aged or elderly

  • cold dry weather
  • infection stress, sleep deprevation, sweat, emotional stress
  • comorbid condition like pityriasis versicolor, psychiatric disorders, lcoholic pancreatitis or hepatitis C or hyperandrogen syndromes in females
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18
Q

what drugs are knwon to cause SD

A
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19
Q

diagnosing dadruff vs SD

A
  • dandruff = Dry, white scales scattered diffusely over scalp

SD: Greasy, yellowish scales on face parts and scalp or eddish-brown fine scaling patches on trunk and body folds

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20
Q

compare features of dandrugg, SD and psoriasis

lesions

common sites

A
  • lesions
    • Dandruff: fine diffuse scales
    • SD: erythema with mild greasy yellow scales, plauqes w/ indistinct margins
    • Psoriasis: anular silvery scaly plaques w/ erythematous base, bleed easy
  • common sites
    • Dandruff: scalp
    • SD: scalp: cntral face, mid chest
    • Psoriasis: scalp, eblows, knees, sacrum
21
Q

compare features of dandruff Sd and psoriasis

palms/soles/nails

intertrigo (skin fold involvement)

Pruritis

assosiated systemic symp

A
  • palms/soles/nails
    • Dandruff: no
    • SD: no
    • Psoriasis: common
  • intertrigo (skin fold involvement)
    • Dandruff: no
    • SD: inverse type, plans penis, mostly infants
    • Psoriasis: common
  • Pruritis
    • Dandruff: due to dryness
    • SD: varie, more common if scalp/ ear canal involed
    • Psoriasis: sometimes
  • assosiated systemic symp
    • Dandruff: none
    • SD: infants or HIV patients
    • Psoriasis: may gneralaize, psoriatic arthritis
22
Q

describe infantile seborrhiec dermatitis

A
  • benign and self-limiting, a conservative approach should be taken
  • managment can include freq cleaning with mild non medicated shamoo and gentle brushing of scalp with soft breush
  • addition of topical products to brushing to help facilitate scale removal, if desired
23
Q

non pharm measures for Dandruff and SD

A
  • disc aggregative facors
  • avoid irritaing sopa,s heavy gels, hairsprays and greasy creams
  • keep hair short and heard trimmed
  • avoid use of excessively hot water as it may dry out the skin
  • use of a cool air humidifer or dish of water to add mositure to indoor env
  • exposure of affected area to sunlight and warm weather
  • trat affected eyelids with warm compress, and genlte washing
  • use non medicated shampoos, freq shampooing is key to control symptolms
24
Q

shampoo considerations for dandrugg and SD

A
  • freq shampooing (at least 3 times weekly) is key to controlling symptoms
  • longer period of lathering may also be helpful in the case of dandruf
  • Shampoos with surfactants (e.g., sodium lauryl sulfate) and detergents are better able to remove scales
  • Patients who develop itching may decrease shampooing due to the drying effect but can lead to further scale accumulation
25
Q

what classes of medications are used to treat dandruff and SD

A

antifungal agents, anti-inflammatory agents and keratolytics.

  • Moisturizers play an ancillary role for softening of scale

*use topical therapy first, oral treatment for more severe cases or if ivnolves multipel body areas

26
Q

ciclopirox olamine for

Dandruff and Seborrheic Dermatitis treatment

A

aka Loprox (cream, lotion), Stieprox (shampoo)

  • Dosage
    • use shampoo 2-3x weekly or as foten as req
    • rub lotion into affected area BID (can apply to beard, face and body)
  • Onset
    • req 2-3 weeks to see onset and 4 week for pull effect
  • Adverse
    • pruritis, burning
  • Comments
    • alternative to ketoconazole
    • is atient already on corticosteroid cont that for 2-3 week while waiting for antifungal to take affect, then withdraw
27
Q

ketoconazole for treatment of dandruff and SD

A

*antifungal

  • Dosage
    • shampoo 2-4 times weekly
    • cream: rub into aa 1d, cna aply to beard,f ace and body
    • prophylaxis/maintenance treatment every 1-2 week
  • Onset
    • req 23 weeks to see effect, full effect @ w4
  • Adverse
    • <1% systemic abs
    • minimal irritation, tiching tinging
    • may cause greasy or dry hair
  • Comments
    • FIRST LIEN TREATMENT
    • if on corticosteroids take those for 2-3 week while waiting for antifungal to take effect then withdraw
28
Q

what if the first line treatment for dardruff and SD

A
  • Ketoconazole
29
Q

selenium sulfide for dandruff and SD

A

antifungal

  • Dosage
    • shampoo 1% or ltoion 2.5%: 2 app/week fof 2 wk then taper down
    • do not use more than 3x/week
  • Onset
    • req 2-4 weeks
  • Adverse
    • excessive use >2x weekly can cause oily ahir and hair loss
    • will sting if applied to broken skin
    • can discolour bleached, tinted or permed ahir
  • COmments
    • second line therapy
    • cannot use on dmaged skin
    • avoi eye area
30
Q

Zinc pyrithione for dandruff SD treatment

A

aka Head and Shoulders Shampoo, Z-Plus Shampoo, others

  • Dosage
    • shampoo: use 2-3x week or as often as req
  • Onset
    • req 2-4 weeks to see effect
  • Adverse
    • may discolor hiar if metal based tins are used
    • safe after perm solutions
  • Comments
    • second line therapy
31
Q

pimecrolimus (Elidel)

A

* Calcineurin inhibitors, topical

  • Dose
    • body: BID
    • maintenace: 1d or 2d/week
  • Onset
    • req 2-4 weeks to see effect
    • meed to maintain to keep condition under contorl
  • Advese
    • mild and transier skin burning at onset
    • lacks long term seide effects fo topical corticosteroids
32
Q

tacrolimus Protopic

A

* Calcineurin inhibitors, topical

  • Dose
    • thin layer aa BID
    • maintenance: 1d 2 days/week
  • Onset
    • 2-4 weeks to see effect, need to maintain use to keep udner control
  • Adverse
    • Mild and transient skin burning at onset
    • lacks long term side efects of topical corticosteroids
33
Q

hydrocortisone

A

*topical corticosteroid -> not formualted for scalp

  • dose
    • aa BID-TID
  • Onset
    • 1-2 weeks, reasses after 2 weeks and cont intermittendly if needed
  • Adverse
    • well tol
  • comments
    • useful for suppressing initla inflammation
34
Q

betamethasone valerate lotion

A

* Corticosteroids, topical (formulated for scalp)

  • dose:
    • app thin film BID to TID
  • Onset:
    • treat 1-2 weeks to see efect, reasses after 2 weeks and cont intermittently if needed
  • adverse
    • burning/irritation at aplication site, pruritus, dryness, atrophy
  • COmments
    • moderate poency topical corticosteroid
    • Severe and thick scales on the scalp can respond to overnight application of topical
35
Q

betamethasone valerate/​salicylic acid

A

* Corticosteroid, topical/keratolytic combination (formulated for scalp)

  • Dose
    • app thin film 1d-BID to scalp
  • Onset
    • 1-2 weeks reasses after 2 weeks
  • Adverse:
    • corticosteroid can cause burning, itching, irritation, acneiform eruptions, skin atrophy, striae.
    • keratolyic: erythema, scaling, local irritation.
  • comments:
    • mod potency topicla corticosteroids. severe thick scalon on scalp can respond overnight
36
Q

coal tar

A

*Keratolytic agents

  • doseing
    • ap 1d
  • onset: 2-4 weeks
  • Adverse
    • folliculitis, acne, contact derm, photosyn a fuck ton
  • Comments
    • second line treatment
37
Q

salicylic acid

A

Keratolytic agents

  • Dose
    • Scalp: up to twice weekly
  • Onset
    • 2-4 weeks
  • adverse
    • irritation, redness and peeling
    • irritating to mucus membranes and eyes
    • younger children at higher side efect risk
  • comemnts
    • SA enhances penetration of topical agents though stratum corneum
38
Q

sulfur

A

Keratolytic agents

  • dose
    • apply twice weekly
  • onset
    • 2-4 weeks
  • adverse
    • irritation, redness and peeling
    • irritaiton to muscus membranes
    • children at higer rick os unwated side eff
  • comments
    • in many commerical products
39
Q

what atnifungals are available for SD/ dandruff

A
  • Ketoconazole (first line, Long-term safety is favourable with chronic use, and efficacy is maintained)
  • clotrimazole and miconzaole also effctive but keto prefererd
  • cicloprioz olamine

selenium sulfide (use when 1st line not effective)

  • Zinc pyrithione (use if more severe, not first line)
40
Q

when to sue Topical calcineurin inhibitors

A

these are immunomodualtors

used for SD when topical corticosteroids ar enot tolerated or inapproprait e9liek when on eye lids)

ex: Tacrolimus an pimecrolimus

41
Q

topical corticosteroids

A
  • hydrocortisone 1%
  • effective for dec the symp of SD, reduce pruritus and inflammation
  • onyl for temproary use
42
Q
A
43
Q

Keratolytic Agents

A

helps detach flakes and increase penetration of other topical medications, which can improve their effectiveness.​

  • can be added into other topical therapy if theri repsonse was inadequate
    ex: Salicylic acid, sulfur, and coal tar
44
Q

NHP for dandruff and SD

A

Quassia amara gel: not bad efficaiy after 4 weeks

Tea tree oil: 5%effective and well tolerated in the treatment of dandruff​[72] and facial SD.

aloe vera: 30 % emulsion applied twice daily improved facial SD with no significant adverse effects reported

Solanum chrysotrichum:

45
Q

what parameters to monitor

A

slcaes

thickless of plauqe

redness

surface area involved

extension to other sites or generalization

itch/scratching

distruption of dleep/daily activites

stress/anxiety/derpession

progression of severity

recurrent episodes

46
Q
A
47
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48
Q
A