Derm

Question 1

Urticarial Vasculitis how to Dx?

Answer 1

Dx: skin biopsy

Question 2

Vignette: joint pains and low grade fever painful wheals that last more than 24hours and leave bruises SLE? AI?

Answer 2

Urticarial Vasculitis

Question 3

AI blistering disease older people urticarial plaques to blisters mucosal 10-40% Peripheral Eosinophilia subepidermal = tense bullae Abs to Collagen XVII 2 biopsies lesion and perilesion normal skin

Answer 3

Bullous Pemphigoid

Question 4

80% acquired Liver disease: ETOH, Hemochromatosis, decreased hepatic Scarring numerous milia uroporphyrinogen decarboxylase

Answer 4

Porphyria Cutanea Tarda

Question 5

melanonychia w/concern for malignancy how to Dx?

Answer 5

nail matrix biopsy

Question 6

Rapid fire assoc: Keratin pearls on a skin biopsy

Answer 6

Squamous cell carcinoma

Question 7

What is the inheritance pattern for Hereditary Hemorrhagic Telangiectasia(HHT)?

Answer 7

Autosomal dominant. HHT is also known as Osler-Weber-Randau syndrome

Question 8

Rapid fire assoc:Anti-desmoglein (anti-desmosome) antibodies

Answer 8

Pemphigus vulgaris (blistering)

Question 9

Pruritic, purple, polygonal planar papules and plaques (6 P’s)

Answer 9

Lichen planus

Question 10

Palpable purpura on buttocks/legs, joint pain, abdominal pain (child), hematuria

Answer 10

Henoch-Schönlein purpura (IgA vasculitis affecting skin and kidneys)

Question 11

Fibrous plaques in soft tissue of penis with abnormal curvature

Answer 11

Peyronie disease (connective tissue disorder)

Question 12

Which disease is associated with decreased uroporphyrinogen decarboxylase activity?

Answer 12

Porphyria cutanea tarda

Question 13

What is the rash that is commonly associated with celiac disease?

Answer 13

Dermatitis herpetiformis

Question 14

Which extra-intestinal manifestations can mirror inflammatory bowel disease?

Answer 14

Arthritis and Erythema Nodosum

Question 15

Elastic skin, hypermobility of joints, ↑ bleeding tendency

Answer 15

Ehlers-Danlos syndrome (type V collagen defect, type III collagen defect seen in vascular subtype of ED)

Question 16

What is the treatment of choice of dermatitis herpetiformis?

Answer 16

Dapsone

Question 17

Cutaneous/dermal edema due to connective tissue deposition

Answer 17

Myxedema (caused by hypothyroidism, Graves disease [pretibial])

Question 18

Blue sclera Is associated with what diagnosis?

Answer 18

Osteogenesis imperfecta (type I collagen defect)

Question 19

Arachnodactyly, lens dislocation (upward), aortic dissection, hyperflexible joints Dx?

Answer 19

Marfan Syndrome (fibrillin defect)