Dementia Flashcards

1
Q

What tests can be used to assess cognition?

A

ACE-III
MoCA
FAB

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2
Q

Give some reversible causes of cognitive impairment

A
Delirium
Alcohol
Medication
Metabolic disorders
Depression
Brain lesions
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3
Q

What is the commonest cause of dementia?

A

Alzheimer’s disease

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4
Q

Give some features of Alzheimer’s disease

A

Short-term memory loss
Dysphasia
Dyspraxia
Agnosia

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5
Q

Give some features of vascular dementia

A

Dysphasia
Dyscalculia
Frontal lobe symptoms
Affective symptoms

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6
Q

What are the three syndromes of frontotemporal dementia?

A

Behavioural
Primary progressive aphasia
Semantic dementia

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7
Q

Give some features of the behavioural variant of frontotemporal dementia

A

Behavioural changes
Impulsivity
Loss of social skills
Apathy

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8
Q

Give some features of primary progressive aphasia

A

Non-fluent speech
Lack of grammar
Lack of words

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9
Q

Give some features of semantic dementia

A

Impaired understanding of word meaning

Difficulty retrieving speech

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10
Q

Give any of the two features required for a diagnosis of Lewy Body dementia

A
Visual hallucinations
Fluctuating cognition
REM sleep behaviour disorder
Parkinsonism
Positive DAT scan
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11
Q

For how long must a patient have Parkinsonism to diagnose Parkinsonian dementia?

A

At least 1 year

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12
Q

What imaging is used as standard in Alzheimer’s disease?

A

CT

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13
Q

When is SPECT imaging used?

A

Frontotemporal dementia

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14
Q

When is DaT imaging used?

A

To clarify Parkinson’s plus syndromes

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15
Q

How do the basal ganglia appear in a DaT scan of Parkinson’s plus syndrome?

A

Full stops - should look like commas

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16
Q

What is the main drug class used to treat mild dementia?

A

Cholinesterase inhibitors

17
Q

Give some examples of cholinesterase inhibitors

A

Donepezil
Rivastigmine
Galantamine

18
Q

Which cholinesterase inhibitor is licensed in Parkinson’s plus syndromes?

A

Rivastigmine

19
Q

What is the effect of cholinesterase inhibitors?

A

Increase the amount of ACh in the brain

20
Q

What drug can be started in moderate dementia?

A

Memantine