Day 6, Lecture 2 (Aug 29): Genetics: Population genetics, Hardy-Weinberg equation

Question 1

Population genetics is

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The study of the frequency of alleles in populations, specifically population with diploid organisms

Question 2

In diploid organisms, the allele frequencies in the next generation tend to be similar/identical if the

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• population is large, mating is random, and if there is no selection
  
  • this is named Hardy-Weinberg equilibrium

Question 3

Use of Hardy Weinberg

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Practical applications of the Hardy-Weinberg Equation/Principle

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Question 6

Assumption of the Hardy-Weinberg Equilibrium

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• Allele frequencies do not change from generation to generation
  
  • For any genetic locus, the genotype frequencies can be determined by the relative frequencies of the alleles at the locus

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• Note p is almost 1 (this is the case especially in rare diseases)

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• Using HW prevalence of PKU in population is 1/40,000=q² hence q=1/200, therefore carrier = 2pq, which is about 2q=1/100

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