Danzer Flashcards
True or False: All cell adhesion molecules are membrane-bound.
True
Adhesion domains are an example of _______ evolution, as multiple adhesion domains have evolved in different organisms.
convergent
True or False: The adhesion domain is mostly made of alpha helices.
False, beta sheets
Most CAMs have an _________ domain.
intracellular
_______ junctions involve CAMs and are occluding junctions (act as a barrier).
Tight
In the nervous system, tight junctions are involved in establishing the ________.
blood-brain barrier (BBB)
True or False: Tight junctions do not allow anything to pass through.
False, tight junctions contain pores that allow small lipophilic molecules; there are also channels for active transport
The area postrema (AP) is involved in __________.
vomiting
CAMs are involved in neural tube development via _________.
zippering
Spina bifida is caused by issues with neural tube closure through failure of CAMs to perform ________.
zippering
The movement of immune cells into the brain is mediated by ________.
CAMs
CAM stands for _________.
cell adhesion molecule
What are the five steps of immune cell movement past the BBB.
Tethering, Rolling, Activation, Firm adhesion, Transmigration
_________, a type of CAM, are involved in axon pathfinding.
Ephrins
True or False: Both chemical and electrical synapses require CAMs.
True
______ junctions are important for communication, allowing electrical currents and small molecules to move through.
Gap
