Plas 2

Question 1

Death receptors are involved in ________ apoptosis.

Answer 1

extrinsic

Question 2

DISC stands for _____________.

Answer 2

Death-inducing Signaling Complex

Question 3

Extrinsic apoptosis uses caspase ___, while intrinsic apoptosis uses caspase __.

Answer 3

8, 9

Question 4

The Death Domain (DD) in Death receptors is located on the ________ portion.

Answer 4

intracellular

Question 5

True or False: Extrinsic apoptosis has three types.

Answer 5

False, there are two types

Question 6

FLIP is involved in _________ of extrinsic apoptosis.

Answer 6

inhibition

Question 7

Failure of ___________ allows necroptosis.

Answer 7

caspase 8

Question 8

True or False: Necroptosis is lytic.

Answer 8

True

Question 9

Pyroptosis involves the activation of the __________ with caspases.

Answer 9

inflammasome

Question 10

____________ is the beginning of ferroptosis.

Answer 10

Fatty acid peroxidation

Question 11

What is the effect of c-FLIP on Type I and Type II extrinsic apoptosis?

Answer 11

Medium c-FLIP will suppress Type I, but not do anything to Type II; high c-FLIP will suppress both.