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MRCP Combined > Cytotoxic Agents > Flashcards

Cytotoxic Agents Flashcards

1
Q

Cyclophosphamide MOA

A

Alkylating agent - causes cross linking in DNA

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2
Q

Cyclophosphamide Adverse effects

A

Haemorrhagic cystitis, myelosuppression, transitional cell carcinoma

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3
Q

Bleomycin MOA

A

Degrades preformed DNA

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4
Q

Bleomycin Adverse effects

A

Lung fibrosis

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5
Q

Anthracyclines (doxorubicin) MOA

A

Stabilises DNA-topoisomerase II complex - inhibits DNA / RNA synthesis

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6
Q

Anthracyclines (doxorubicin) adverse effects

A

Cardiomyopathy

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7
Q

methotrexate MOA

A

inbihits dihydrofolate reductase and thymidylate synthesis

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8
Q

Methotrexate adverse effects

A

Myelosuppression, mucositis, liver fibrosis, lung fibrosis

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9
Q

5-FU MOA

A

pyrimidine analogue, inducing cell cycle arrest and apoptosis by blocking thymidylate synthase

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10
Q

5-FU Adverse effects

A

myelosuppression, mucostis, dermatitis

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11
Q

6-mercaptopurine MOA

A

Purine analogue that is activated by HGPRTase, decreasing purine synthesis

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12
Q

6-mercaptopurine adverse effects

A

Myelosuppression

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13
Q

Cytarabine moa

A

Pyrimidine antagonist. interferes with DNA synthesis specifically at the S-phase of the cell cycle and inhibits DNA polymerase

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14
Q

Cytarabine adverse effects

A

Myelosuppression, ataxia

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15
Q

Vincristine MOA

A

Inhibits formation of microtubles

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16
Q

Vincristine adverse effects

A

vincristine: Peripheral neuropathy, paralytic ileus
vinblastine: myelosuppression

17
Q

Docetaxel MOA

A

Prevents microtubule depolymerisation and disassembly, decreasing free tubulin

18
Q

Docetaxel adverse effects

A

Neutropenia

19
Q

Irinotecan MOA

A

Inhibits topoisomerase I which prevents relaxation of supercoiled DNA

20
Q

Ironitecan adverse efects

A

Myelosuppression

21
Q

Cisplatin MOA

A

Causes cross-linking in DNA

22
Q

Cisplatin Adverse effects

A

Ototoxicity, peripheral neuropathy, hypomagnesaemia

23
Q

Hydroxyurea MOA

A

Inhibits ribonucleotide reductase, decreasing DNA synthesis

24
Q

Hydroxyurea adverse effects

A

Myelosuppression

MRCP Combined (58 decks)

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