Anti-fungal agents

Question 1

azoles MOA

Answer 1

Inhibits 14α-demethylase which produces ergosterol

Question 2

Azoles adverse effects

Answer 2

P450 inhibition
Liver toxicity

Question 3

Amphotericin B MOA

Answer 3

Binds with ergosterol forming a transmembrane channel that leads to monovalent ion (K+, Na+, H+ and Cl) leakage

Question 4

Amphotericin B adverse effects

Answer 4

Nephrotoxicity, flu-like symptoms, hypokalaemia, hypomagnaseamia

Question 5

Amphotericin B uses

Answer 5

Used for systemic fungal infections

Question 6

Terbinafine MOA

Answer 6

Inhibits squalene epoxidase

Question 7

terbafine actions

Answer 7

Commonly used in oral form to treat fungal nail infections

Question 8

Griseofulvin MOA

Answer 8

Interacts with microtubules to disrupt mitotic spindle

Question 9

griseofulvin adverse effects

Answer 9

Induces P450 system, teratogenic

Question 10

Flucytosine MOA

Answer 10

Converted by cytosine deaminase to 5-fluorouracil, which inhibits thymidylate synthase and disrupts fungal protein synthesis

Question 11

Flucytosine adverse effect

Answer 11

Vomiting

Question 12

Caspofungin MOA

Answer 12

Inhibits synthesis of beta-glucan, a major fungal cell wall component

Question 13

Caspofungin adverse effect

Answer 13

Flushing

Question 14

Nystatin MOA

Answer 14

Binds with ergosterol forming a transmembrane channel that leads to monovalent ion (K+, Na+, H+ and Cl) leakage

Question 15

Nystatin use

Answer 15

oral thrush