Cytoskeleton and cell mechanics Flashcards
microtubule
protofilaments go round in a ring where each of them is made up of repetitive alpha and beta(binds GTP) tubular dimers
crystal structure
fuel go to the top which is where alpha is and beta is plus end which gives polarity
kinesin
moves towards plus end and dumps its content outside membrane by moving to plasma membrane
dynein
moves to minus end
b tubulin
binds ADP which swings head forward
Dynein organelle transport
2 knees move rapidly retains attachment to microtubule as it delivers organelle in opposite direction to the nucleus of the cell
hydrolisation
ATP binding force generating stroke pushes dynein then releasing from microtubule to bind the head back down to ADP then goes to minus head
neurofilament
consists of obligate heterodimer which helps with support of axon and gilal cells