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Immunology/Microbiology > Cytokines > Flashcards

Cytokines Flashcards

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1
Q

IL1 is made by

A

monocytes, macrophages, B cells, dendritic cells and endothelial cells

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2
Q

The target tissues for IL1 are

A

Th cells
Hepatocytes
Hypothalamus

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3
Q

The function if IL1 is

A

costimulatory, acute phase induction, fever production

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4
Q

IL2 is made by

A

Th1 cells

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5
Q

The target tissue of IL2 is

A

activated Th cells and cytotoxic lymphocytes

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6
Q

The function if IL2 is

A

proliferation and enhanced killing

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7
Q

IL3 is made by

A

The helper cells

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8
Q

The target tissue for IL3 is

A

hematopoietic cells

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9
Q

the function of IL3 is

A

growth factor

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10
Q

IL4 is made by

A

Th2 cells

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11
Q

IL4 target tissue is

A

B cells

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12
Q

IL4 function

A

activation class switching to IgE and IgG

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13
Q

IL5 is made by

A

Th2 cells

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14
Q

IL5 target tissue is

A

B cells

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15
Q

Activity of IL5 is

A

class switching to IgA

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16
Q

IL6 is activated by

A

macrophages and Th2 Cells

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17
Q

The target tissue for IL6 is

A

B cells hepatocytes, and hypothalamus

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18
Q

The activity of IL6 is

A

differentiation in to plasma cells and Ab production
acute phase protein induction
fever production

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19
Q

IL7 is secreted by

A

bone marrow, thymic stromal cells

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20
Q

target tissue for IL7 is

A

B and T cell precursors

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21
Q

Function if IL7

A

differentation

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22
Q

IL-8 is secreted by

A

macrophages

23
Q

IL-8 target cell or tissue is

A

neutrophil

24
Q

Activity of IL8 is

A

chemotaxis

25
Q

IL-10 is secreted by

A

macrophages

26
Q

Target tissue for IL-10 is

A

macrophaes and Th2 cells

27
Q

Activity of IL-10 is

A

down regulation of the inflammatory response

28
Q

IL-12 is secreted by

A

macrophages

29
Q

target tissue for IL-12 is

A

Th cells

30
Q

Function if IL-12 is

A

promotes differentiation of Th cells into Th1 cells

31
Q

IFN-alpha and IFN-beta is secreted by

A

luekocytes and fibroblasts

32
Q

target cell tissue for IFN-alpha and beta is

A

infected cells

33
Q

action of IFN-alpha and beta

A

inhibits viral production

34
Q

IFN-gamma is secreted by

A

Th1 cells

35
Q

target cell tissue for IFN gamma is

A

macrophages

36
Q

IGN-gamma function is

A

activation of macrophages

37
Q

TNF-alpha is secreted by

A

macrophages

38
Q

target cell tissue for TNF-alpha is

A

inflammatory cells

39
Q

Function of TNF-alpha is

A

induces cytokine secretion and cachexia

40
Q

G-CSF and GM-CSF is secreted by ______________, target cell tissue is _______________ and activity is ______________

A

macrophages and Th cells
bone marrow precursors
granulocyte development

41
Q

______is used to boot immunity during chemoteryapy

A

GM-CSF

42
Q

__________is used to boot immunity prior to BMT

A

G-CSF

43
Q

________is used to treat anemai

A

EPO

44
Q

____________attracts T cells and monocytes

A

RANTES

45
Q

_________ and IL18 induce IFN-gamma production of TH1 cells

A

IL12

46
Q

IL-12 inducdes differentaion of

A

TH to Th1

47
Q

anti IL-4 used for

A

treating serious allergies

48
Q

_________is used to increases success of organ transplants, and experimental treatment of leukemia and melanomas

A

IL-2

49
Q

________is used to treat RA

A

IL-6 inhibitors

50
Q

monoclonal antibodies to inhibit TNF-alpha are used to treat what diseases

A

RA, chrons disease and psoriasis

51
Q

________is used to treat HBV, HCV, and HHV-8

A

IFN alpha

52
Q

_______used to treat MS

A

IFN-beta

53
Q

________is used to treat GCD

A

IFN-gamma

Immunology/Microbiology (10 decks)

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