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8. Psychopharmacology > CYP General Review > Flashcards

CYP General Review Flashcards

1
Q

fluvoxamine INHIBITS which CYP enzymes

A

1A2+++

2C19+++

3A4+++

2C9

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2
Q

Valproic Acid INHIBITS which CYP enzymes

A

2C9 +

UGT

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3
Q

NSAIDs INHIBITS which CYP enzymes

A

UGT

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4
Q

Fluoxetine INHIBITS which CYP enzymes

A

2D6+++

1A2+

2C9++

2C19+

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5
Q

Paroxetine INHIBITS which CYP enzymes

A

1A2

2D6 +++

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6
Q

Buproprion INHIBITS which CYP enzymes

A

2D6+++

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7
Q

Sertraline INHIBITS which CYP enzymes

A

1A2+

2D6+

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8
Q

Citalopram INHIBITS which CYP enzymes

A

2D6 +

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9
Q

Escitalopram INHIBITS which CYP enzymes

A

2D6+

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10
Q

haldol INHIBITS which CYP enzymes

A

2D6+

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11
Q

Fluconazole INHIBITS which CYP enzymes

A

2C9 +++

3A4+++

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12
Q

Amiodarone INHIBITS which CYP enzymes

A

2C9 ++

2D67 +

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13
Q

Caffeine INHIBITS which CYP enzymes

A

1A2

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14
Q

Grapefruit juice INHIBITS which CYP enzymes

A

3A4

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15
Q

OCP INHIBITS which CYP enzymes

A

1A2

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16
Q

Clarithromycin, Erythromycin INHIBITS which CYP enzymes

A

3A4+++

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17
Q

Tobacco INDUCES which CYP enzymes

A

1A2

3A4+ (NICOTINE)

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18
Q

Carbamazepine INDUCES which CYP enzymes

A

3A4+++

UGT++

1A2

2C9

2C19

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19
Q

phenytoin INDUCES which CYP enzymes

A

3A4+++

UGT++

1A2

2C19

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20
Q

Valproic Acid INDUCES which CYP enzymes

A

2C19

(+inhibits UGT and 2C9)

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21
Q

St. Johns Wort INDUCES which CYP enzymes

A

3A4++

1A2

2C19

2C9

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22
Q

Lamotrigine INDUCES which CYP enzymes

A

UGT

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23
Q

Topiramate INDUCES which CYP enzymes

A

3A4+

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24
Q

Morphine INDUCES which CYP enzymes

A

3A4+

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25
Q

Rifampin INDUCES which CYP enzymes

A

3A4+++

2C9

2C19

1A2

UGT +

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26
Q

GLucocorticoids INDUCES which CYP enzymes

A

3A4

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27
Q

Nefazodone INHIBTIS which CYP enzymes

A

3A4+++

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28
Q

Caffeine is a SUBSTRATE of which CYP enzymes

29
Q

Theophylline is a SUBSTRATE of which CYP enzymes

30
Q

Tamoxifen is a SUBSTRATE of which CYP enzymes

31
Q

Warfarin is a SUBSTRATE of which CYP enzymes

A

1A2

2C19

2C9

32
Q

NSAIDs is a SUBSTRATE of which CYP enzymes

33
Q

what is the CYP interaction we most associate with smoking and clozapine

A

via 1A2, smoking causes clozapine levels to go down

34
Q

OCP is a SUBSTRATE of which CYP enzymes

35
Q

what is the major psychotropic inhibitor of 3A4

A

fluvoxamine

36
Q

TCAs is a SUBSTRATE of which CYP enzymes

37
Q

Clozapine is a SUBSTRATE of which CYP enzymes

A

1A2+++

2D6

3A4

2C19

UGT

38
Q

olanzapine is a SUBSTRATE of which CYP enzymes

39
Q

Risperidone is a SUBSTRATE of which CYP enzymes

A

1A2

2D6++

3A4++

UGT

40
Q

which CYP enzyme is responsible for the relationship between risperidone/ability and fluoxetine

41
Q

which CYP enzyme is responsible for the relationship between risperidone/ability and fluvoxamine

42
Q

Abilify is a SUBSTRATE of which CYP enzymes

A

2D6++

3A4++

UGT

43
Q

Duloxetin is a SUBSTRATE of which CYP enzymes

44
Q

Mirtazapine is a SUBSTRATE of which CYP enzymes

A

1A2++

3A4++

45
Q

non LOT benzos is a SUBSTRATE of which CYP enzymes

46
Q

LOT benzos is a SUBSTRATE of which CYP enzymes

47
Q

lamotrigine is a SUBSTRATE of which CYP enzymes

48
Q

fluvoxamine is a SUBSTRATE of which CYP enzymes

49
Q

sertraline is a SUBSTRATE of which CYP enzymes

A

2D6

3A4++

2C19

2C9

2B6

50
Q

buproprion is a SUBSTRATE of which CYP enzymes

51
Q

buprenorphine is a SUBSTRATE of which CYP enzymes

52
Q

methadone is a SUBSTRATE of which CYP enzymes

53
Q

codeine is a SUBSTRATE of which CYP enzymes

54
Q

morphine is a SUBSTRATE of which CYP enzymes

55
Q

venlafaxine is a SUBSTRATE of which CYP enzymes

56
Q

escitalopram, citalopram is a SUBSTRATE of which CYP enzymes

A

2D6

2C19

3A4–escitalopram only

57
Q

paroxetine is a SUBSTRATE of which CYP enzymes

58
Q

atomoxetine is a SUBSTRATE of which CYP enzymes

59
Q

dexamethasone is an inducer of which cyp enzymes

60
Q

propanolol is a SUBSTRATE of which CYP enzymes

61
Q

inhibition of 1A2 increases serum levels of which meds/substances

A

olanzapine
risperidone
theophylline
warfarin
agomelatine
clozapine
duloxetine

naproxen
caffeine

62
Q

inhibition of 2C19 increases serum levels of which meds/substances

A

propanolol
warfarin
antiepileptics

63
Q

inhibition of 2D6 increases serum levels of which meds/substances

A

olanzapine
risperidone
vortioxetine
tamoxifen–> and REDUCES effect
codeine
TCAs
beta blockers
tramadol

64
Q

inhibition of 3A4 increases serum levels of which meds/substances

A

haldol
levomilnacipran
methadone
quetiapine
tamoxifen
vilazodone
statins

65
Q

name an antipsychotic that has minimal or low risk of drug-drug interactions

A

paliperidone (does not undergo first pass metabolism)

66
Q

list 3 antipsychotics with HIGH risk of drug-drug interactions

A

clozapine (3A4, 1A2 substrate)
lurasidone (3A4 substrate)
quetiapine (3A4 substrate)

67
Q

list 3 antipsychotics with moderate risk for drug-drug interaction

A

abilify (2D6, 3A4 substrate)
risperidone (3A4, 2D6 substrate)
olanzapine (1A2 substrate)

68
Q

list antidepressants with HIGH risk for drug-drug interactions

A

fluoxetine (2D6, 2C19 inhibitor)
fluvoxamine (1A2, 2C19, 3A4 inhibitor)
moclobemide (MAOi precautions)
paroxetine (2D6 inhibitor)
selegiline (MAOi precautions)

69
Q

list antidepressants with low risk for drug-drug interactions

A

citalopram
escitalopram
desvenlafaxine
mirtazapine
venlafaxine

8. Psychopharmacology (21 decks)

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