CYP 2D6 Review Flashcards

Question 1

Q

Fluoxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

POTENT INHIBITOR

substrate

Question 2

Q

Risperidone

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

major substrate

Question 3

Q

Dexamethasone

CYP 2D6 Inducer, Substrate or Inhibitor?

Question 4

Q

name the significant psychotropic medication inducers of CYP 2D6

Answer

A

there are NONE!

Question 5

Q

Fluvoxamine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

major substrate

Question 6

Q

Buproprion

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

POTENT INHIBITOR

Question 7

Q

methadone

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

inhibitor

Question 8

Q

TCAs

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 9

Q

Venlafaxine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

major substrate

inhibitor

Question 10

Q

Duloxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

major inhibitor

Question 11

Q

Paroxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

POTENT INHIBITOR

major substrate

Question 12

Q

Aripiprazole

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

major substrate

Question 13

Q

Sertraline

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

inhibitor

substrate

Question 14

Q

Codeine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 15

Q

Tamoxifen

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 16

Q

Tramadol

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 17

Q

citalopram

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

inhibitor

Question 18

Q

escitalopram

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

inhibitor

Question 19

Q

Ritonavir

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

inhibitor

Question 20

Q

Asenapine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

inhibitor

Question 21

Q

Haloperidol

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

inhibitor

Question 22

Q

beta blockers

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 23

Q

clozapine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 24

Q

olanzapine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 25

Q

vortioxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 26

Q

atomoxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer

A

substrate

Question 27

Q

What is the concern about prescribing risperidone and fluoxetine together

Answer

A

fluoxetine = inhibitor at 2D6 and risperidone = major substrate at 2D6

Rx of fluoxetine with risperidone INCREASES levels of risperidone

Question 28

Q

which antidepressants should be considered carefully in someone on abilify

Answer

A

fluoxetine
paroxetine
buproprion
–> all are potent inhibitor at 2D6 and abilify is a major substrate of 2D6–> could increase abilify levels

can DECREASE DOSE OF ABILIFY if you start one of these antidepressants and start to get side effects of abilify

Question 29

Q

list the 2D6 inhibitors

Answer

A

Fluoxetine +++
Paroxetine +++
Buproprion +++
Duloxetine ++
Sertraline +
Methadone
Ritonavir
Citalopram
Escitalopram
Asenapine
Haloperidol
Venlafaxine
Clomipramine

Question 30

Q

list the CYP 2D6 substrates

Answer

A

Fluoxetine
Fluvoxamine
Paroxetine
Risperidone
Aripiprazole
Venlafaxine
TCAs

Clozapine
Olanzapine
Haloperidol
Citalopram
Escitalopram
Sertraline
Duloxetine
Vortioxetine
Atomoxetine

Codeine
Tamoxifen
Tramadol
Beta blockers

Question 31

Q

List the 2D6 inducers

Answer

A

Rifampin
Dexamethasone