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8. Psychopharmacology > CYP 2D6 Review > Flashcards

CYP 2D6 Review Flashcards

1
Q

Fluoxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

substrate

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2
Q

Risperidone

CYP 2D6 Inducer, Substrate or Inhibitor?

A

major substrate

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3
Q

Dexamethasone

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inducer

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4
Q

name the significant psychotropic medication inducers of CYP 2D6

A

there are NONE!

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5
Q

Fluvoxamine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

major substrate

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6
Q

Buproprion

CYP 2D6 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

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7
Q

methadone

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inhibitor

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8
Q

TCAs

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

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9
Q

Venlafaxine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

major substrate

inhibitor

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10
Q

Duloxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

major inhibitor

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11
Q

Paroxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

major substrate

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12
Q

Aripiprazole

CYP 2D6 Inducer, Substrate or Inhibitor?

A

major substrate

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13
Q

Sertraline

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inhibitor

substrate

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14
Q

Codeine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

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15
Q

Tamoxifen

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

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16
Q

Tramadol

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

17
Q

citalopram

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inhibitor

18
Q

escitalopram

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inhibitor

19
Q

Ritonavir

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inhibitor

20
Q

Asenapine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inhibitor

21
Q

Haloperidol

CYP 2D6 Inducer, Substrate or Inhibitor?

A

inhibitor

22
Q

beta blockers

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

23
Q

clozapine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

24
Q

olanzapine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

25
Q

vortioxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

26
Q

atomoxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

A

substrate

27
Q

What is the concern about prescribing risperidone and fluoxetine together

A

fluoxetine = inhibitor at 2D6 and risperidone = major substrate at 2D6

Rx of fluoxetine with risperidone INCREASES levels of risperidone

28
Q

which antidepressants should be considered carefully in someone on abilify

A

fluoxetine
paroxetine
buproprion
–> all are potent inhibitor at 2D6 and abilify is a major substrate of 2D6–> could increase abilify levels

can DECREASE DOSE OF ABILIFY if you start one of these antidepressants and start to get side effects of abilify

29
Q

list the 2D6 inhibitors

A

Fluoxetine +++
Paroxetine +++
Buproprion +++
Duloxetine ++
Sertraline +
Methadone
Ritonavir
Citalopram
Escitalopram
Asenapine
Haloperidol
Venlafaxine
Clomipramine

30
Q

list the CYP 2D6 substrates

A

Fluoxetine
Fluvoxamine
Paroxetine
Risperidone
Aripiprazole
Venlafaxine
TCAs

Clozapine
Olanzapine
Haloperidol
Citalopram
Escitalopram
Sertraline
Duloxetine
Vortioxetine
Atomoxetine

Codeine
Tamoxifen
Tramadol
Beta blockers

31
Q

List the 2D6 inducers

A

Rifampin
Dexamethasone

8. Psychopharmacology (21 decks)

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