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8. Psychopharmacology > CYP 1A2 Review > Flashcards

CYP 1A2 Review Flashcards

1
Q

Fluvoxamine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

substrate

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2
Q

Clozapine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

major substrate

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3
Q

Carbamazepine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inducer

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4
Q

St. John’s Wort

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inducer

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5
Q

TCAs

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Substrate

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6
Q

Tobacco/smoking

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inducer

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7
Q

Fluoxetine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inhibitor

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8
Q

Caffeine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

INHIBITOR

+substrate

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9
Q

Olanzapine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Substrate

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10
Q

Duloxetine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Substrate

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11
Q

Mirtazapine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Substrate

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12
Q

Paroxetine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inhibitor

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13
Q

Modafinil

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inducer

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14
Q

Sertraline

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inhibitor

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15
Q

Theophylline

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Substrate

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16
Q

OCP

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Strong Inhibitor

17
Q

Estradiol

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Strong Inhibitor

18
Q

Ciprofloxacin

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inhibitor

19
Q

Risperidone

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Substrate

20
Q

Asenapine

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Substrate

21
Q

Phenytoin

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Inducer

22
Q

Haldol

CYP 1A2 Inducer, Substrate or Inhibitor?

A

Susbtrate

23
Q

What effect would prescribing fluvoxamine have on Clozapine levels in a patient already on clozapine

A

would increase clozapine levels–> fluvoxamine is a potent 1A2 inhibitor and clozapine is a 1A2 substrate

24
Q

What effect would prescribing carbamazepine have on duloxetine levels if they were to be co prescribed

A

decreased duloxetine levels–> carbamazepine is an inducer of 1A2, and duloxetine is a 1A2 substrate

25
Q

Name an antidepressant you should not prescribe with theophylline

A

fluvoxamine –> potent 1A2 inhibitor

–> also avoid sertraline, fluoxetine and paroxetine, but fluvoxamine is the worst

26
Q

St. Johns Wort can work to DECREASE levels of which psychiatric medications?

A

Clozapine
Duloxetine
Fluvoxamine
Olanzapine
Mirtazapine
TCAs
Risperidone
Asenapine
Haldol

27
Q

list the CYP 1A2 inhibitors

A

Fluvoxamine +++
Fluoxetine
Paroxetine
Sertraline

OCP ++
Estradiol ++
Caffeine

Cipro, cimetidine, fluoroquinolones

28
Q

List the inducers of CYP 1A2

A

Carbamazepine
St. Johns Wort
Phenytoin
Modafinil
Phenobarbital

Tobacco/Smoking

Rifampin, ritovanir, omeprazole

29
Q

List the substrates of CYP1A2

A

Clozapine
Fluvoxamine
Duloxetine
Mirtazapine
Olanzapine
TCAs
Risperidone
Asenapine
Haldol
Agomelatine
Ropinirole

Theophylline
Warfarin
Caffeine
Naproxen

8. Psychopharmacology (21 decks)

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