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8. Psychopharmacology > CYP 3A4 Review > Flashcards

CYP 3A4 Review Flashcards

1
Q

Fluovxamine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

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2
Q

Escitalopram

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

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3
Q

Grapefruit juice

CYP 3A4 Inducer, Substrate or Inhibitor?

A

inhibitor

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4
Q

Carbamazepine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

inducer

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5
Q

Aripiprazole

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

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6
Q

Risperidone

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

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7
Q

Nefazodone

CYP 3A4 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

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8
Q

St. Johns Wort

CYP 3A4 Inducer, Substrate or Inhibitor?

A

POTENT INDUCER

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9
Q

Rifampin

CYP 3A4 Inducer, Substrate or Inhibitor?

A

POTENT INDUCER

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10
Q

Nicotine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

Inducer

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11
Q

Quetiapine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

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12
Q

Erythromycin

CYP 3A4 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

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13
Q

Statins

CYP 3A4 Inducer, Substrate or Inhibitor?

A

Major substrate

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14
Q

Methadone

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

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15
Q

Buprenorphine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

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16
Q

ketoconazole

CYP 3A4 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

17
Q

Lurasidone

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

18
Q

Sertraline

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

19
Q

Clozapine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

substrate

20
Q

Mirtazapine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

21
Q

Topirmate

CYP 3A4 Inducer, Substrate or Inhibitor?

A

inducer

22
Q

Ritonavir

CYP 3A4 Inducer, Substrate or Inhibitor?

A

POTENT INHIBITOR

23
Q

Morphine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

inducer

24
Q

Efavirenz

CYP 3A4 Inducer, Substrate or Inhibitor?

A

inducer

25
Q

Trazodone

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

26
Q

OCP

CYP 3A4 Inducer, Substrate or Inhibitor?

A

major substrate

27
Q

Venlafaxine

CYP 3A4 Inducer, Substrate or Inhibitor?

A

substrate

28
Q

Levomilnacipran

CYP 3A4 Inducer, Substrate or Inhibitor?

A

substrate

29
Q

ziprazidone

CYP 3A4 Inducer, Substrate or Inhibitor?

A

substrate

30
Q

Tamoxifen

CYP 3A4 Inducer, Substrate or Inhibitor?

A

substrate

31
Q

non LOT benzos

CYP 3A4 Inducer, Substrate or Inhibitor?

A

substrate

32
Q

Tacrolimus

CYP 3A4 Inducer, Substrate or Inhibitor?

A

substrate

33
Q

Verapamil

CYP 3A4 Inducer, Substrate or Inhibitor?

A

strong inhibitor

34
Q

List the 3A4 Inhibitors

A

Fluvoxamine +++
Nefazodone +++
Erythromycin +++
Ketoconazole +++
Ritonavir +++
Grapefruit juice
Verapamil
Diltiazem

35
Q

List the 3A4 substrates

A

Quetiapine
Abilify
Risperidone
Lurasidone
Escitalopram
Sertraline
Mirtazapine
Trazodone

Clozapine
Venlafaxine
Ziprasidone
Vilazodone
Buspirone
Haldol
Pimozide
non LOT benzos

Methadone
Buprenorphine
OCP
Statins
Acetaminophen
Tacrolimus
Tamoxifen

36
Q

List the 3A4 inducers

A

Carbamazepine
St. Johns Wort +++
Morphine +
Nicotine +
Topiramate +
Phenytoin
Phenobarbital
Rifampin +++
Efavirenz

8. Psychopharmacology (21 decks)

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