CVS: Ramipril

Question 1

What class of Meds is Ramipril?

Answer 1

ACE inhibitor

Question 2

What does Ramipril treat? (5 things)

Answer 2

1. HTN
2. HF
3. Post-MI prophylaxis in HF pt
4. CVS prophylaxis in DM / Atherosclerotic pt
5. Nephropathy

Question 3

What is the GENERAL MOA of Ramipril?

Answer 3

Antagonises RAAS system

Question 4

What is the IN-DEPTH MOA of Ramipril? (3 steps)

Answer 4

1. Binds to + Inhibits ACE
2. Prevents Angiotensin I –> Angiotensin II conversion
3. No more Angiotensin II, so instead:
   
   • Vasodilation
   • Reduced inflammation

Question 5

What route should Ramipril be given?

Answer 5

Oral

Question 6

What are the Min / Max Doses for Ramipril?

Answer 6

• Min: 1.25mg OD
• Max: 10mg OD

Question 7

What are the Monitoring Requirements for Ramipril?

Answer 7

Check Renal function + Electrolytes b4 starting / increasing dose / during tx

Question 8

What are the Side fx of Ramipril? (6 things)

Answer 8

1. Dry cough
2. Dizzy (esp when you get up)
3. Headaches
4. Vomiting / Diarrhoea
5. Rash
6. Blurred vision

Question 9

What advice should you tell a patient taking Ramipril?

Answer 9

First dose to be taken at bed time

Question 10

What are the CI for taking Ramipril? (2 things)

Answer 10

1. Angioedema
2. Hx of angioedema w previous ACEi Tx

Question 11

When should Ramipril be used with Caution? (7 things)

Answer 11

1. Diuretics
2. DM (risk of hypoglycaemia + hyperkalaemia)
3. Niggas
4. PVD
5. Primary aldosteronism
6. Aortic / Mitral stenosis (risk of hypotension)
7. Hypertrophic cardiomyopathy