CVS: Losartan

Question 1

What class of Meds is Losartan?

Answer 1

Angiotensin II receptor antagonist

Question 2

What does Losartan treat? (3 things)

Answer 2

1. HTN
2. Diabetic nephropathy
3. HF (when ACEi CI)

Question 3

What is the GENERAL MOA of Losartan?

Answer 3

Reversibly + Competitively prevents Angiotensin II binding to receptors in Vasc SMC + Adrenal Gland

Question 4

What is the IN-DEPTH MOA of Losartan? (3 steps)

Answer 4

1. Prevents Angiotensin II binding to receptors
2. Vascular SMC relaxation
3. Lowers BP

Question 5

What route should Losartan be given?

Answer 5

Oral

Question 6

What are the Min / Max Doses for Losartan?

Answer 6

• Min: 25mg OD
• Max: 150mg OD

Question 7

What are the Monitoring Requirements for Losartan? (3 things)

Answer 7

1. Monitor plasma-Potassium conc
2. Hypotension
3. Renal function

Question 8

What are the Side fx of Losartan? (5 things)

Answer 8

1. Dizziness
2. Nausea
3. Anaemia
4. Hypoglycaemia
5. Postural hypotension

Question 9

What are the CI for taking Losartan?

Answer 9

None

Question 10

When should Losartan be used with Caution? (7 things)

Answer 10

1. Elderly (start with low doses)
2. Niggas
3. Angioedema Hx
4. Aortic / Mirtal Stenosis
5. Hypertrophic cardiomyopathy
6. Primary aldosteronism
7. Renal artery stenosis