CVS: Bendroflumethiazide

Question 1

What class of Meds is Bendroflumethiazide?

Answer 1

Thiazide diuretics

Question 2

What does Bendroflumethiazide treat? (4 things)

Answer 2

1. HTN
2. Familial hyperkalaemia
3. Oedema
4. Urinary tract disorders

Question 3

What is the GENERAL Diuretic MOA of Bendroflumethiazide? (2 steps)

Answer 3

1. Inhibits Chloride reabsorption @ Distal Tubule (via Na-Cl cotransporter)
2. This increases Excretion of: Na, Cl, H2O

Question 4

What is the THIAZIDE Diuretic MOA of Bendroflumethiazide? (2 steps)

Answer 4

1. Inhibits Na transport across Renal Tubular Epithelium (by binding to Thiazide sensitive NaCl transporter)
2. This increases Excretion of K (via NK exchanger)

Question 5

What are the Monitoring Requirements for Bendroflumethiazide?

Answer 5

Monitor electrolytes during tx (esp @ high doses / prolonged use)

Question 6

What are the Side fx of Bendroflumethiazide? (3 things)

Answer 6

1. Dizziness
2. Fatigue
3. Vomiting

Question 7

What are the CI for taking Bendroflumethiazide? (5 things)

Answer 7

1. Addison’s disease
2. Hypercalcaemia
3. Hyponatraemia
4. Refractory Hypokalaemia
5. Symptomatic Hyperuricaemia

Question 8

When should Bendroflumethiazide be used with Caution? (4 things)

Answer 8

1. DM
2. Gout
3. Hypokalaemia risk
4. SLE