CV Angiotensin Converting Enzyme

Question 1

Examples of ACEs?

Answer 1

Ramipril, lisinopril, perindopril

Question 2

Indications for ACEs

Answer 2

1. Hypertension
2. Chronic HF
3. Ischaemic heart disease
4. Diabetic nephropathy ans CKD: reduce proteinurea and progression of nephropathy

Question 3

What is the mechanism of action of ACEs?

Answer 3

1. Blocks formation of angio II
2. Results in prevention of AT1 receptor stimulation
3. Decreased Aldosterone secretion and vasodilation
4. Reduce sympathetic activity

Question 4

What are the adverse effects of ACEs?

Answer 4

1. Dry cough (presence of Bradykinin
2. Hypotension
3. Hyperkalaemia
4. Angioedema
5. Urticaria, rashes
6. GI upset

Question 5

Warnings?

Answer 5

1. Avoid in renal artery stenoisi
2. AKI
3. Pregnant and breastfeeding women
4. . CKD (lower doses)

Question 6

Important reactions?

Answer 6

1. Avoid Pxing with other potassium elevating drugs

Question 7

Practical prescribing?

Answer 7

1. ACE taken orally

2. Ramipril 1.25mg