Cutaneous Manifestation of Systemic Disease Flashcards
What are the cutaneous features of diabetes?
- Flexural candidiasis
2. Acanthosis nigricans
What is the key cutaneous feature of coeliac disease?
Dermatitis herpetiformis - itchy blisters on elbows/shoulders
What are the cutaneous features of IBD?
- Erythema nodosum
2. Pyoderma gangrenosum
What are the cutaneous features of SLE?
- Facial butterfly rash
- Photosensitivity
- Diffuse alopecia
What is the key cutaneous feature of systemic sclerosis?
Scleroderma
What is the key cutaneous feature of sarcoidosis?
Lupus pernio
What is this a presentation of?
Chronic sarcoid plaques on nose, ears, lips, and cheeks +/- permanent scarring.
Lupus pernio - sarcoidosis
What is this a presentation of?
Target lesions where the centre is paler, 2cm in size and raised, initially on back of hands/feet before spreading to torso. Mild pruritus.
Erythema multiforme
What is the cause of erythema multiforme?
Hypersensitivity reaction (commonly triggered by infections)
What are the causes of the hypersensitivity reaction which causes erythema multiforme?
- HSV (most common)
- Idiopathic
- Mycoplasma, streptococcus
- Drugs
- Connective tissue disease
- Sarcoidosis
- Malignancy
What is this a presentation of?
‘Bull’s eye’ papule.
Erythema migrans (Lyme disease)
What is the key skin feature of Lyme disease (diagnostic)?
Erythema migrans
What causes erythema migrans and how is it treated?
- Lyme disease
2. Doxycycline
What is erythema nodosum?
Inflammation of the subcutaneous fat
What is this a presentation of?
Tender, erythematous, nodular lesions over shins. Usually resolves in 6 weeks, heals without scarring.
Erythema nodosum
What are the causes of erythema nodosum?
- Streptococcus, TB
- Sarcoidosis, IBD
- Malignancy/lymphoma
- Penicillin, COCP
- Pregnancy
What is this a presentation of?
Non-blanching vague pink-blue mottling.
Livedo reticularis
What is the cause of continuous livedo reticularis?
Physiological (normal), disappears when warm.
What are the causes of discontinuous livedo reticularis?
- Connective tissue disease
- Vasculitis
- Hyperviscosity states
What is this a presentation of?
40-50 years old, pustules become ulcers that progressively grow. Lower limbs, initially small red papule that becomes a deep, red, necrotic ulcer.
Pyoderma gangrenosum
What are the causes of pyoderma gangrenosum?
- Idiopathic in 50%
- IBD/RA/SLE
- Myeloproliferative disorders/leukaemia/lymphomas
How is pyoderma gangrenosum treated?
PO steroids
What is this a presentation of?
Dry, dark patches of skin appearing in armpits/neck/groin.
Acanthosis nigricans
What are the causes of acanthosis nigricans?
- Obesity, insulin resistance
2. Think malignancy (gastric adenocarcinoma in the thin and young)
