CURS 6 SIMPATICOLITICE-incomplet

Question 1

Blocante semi-selective alfa1 si 2

Answer 1

Fentolamina, Ergotamina, complexul Ergotoxina, Dihidroergocristina

Question 2

Blocante selective alfa1

Answer 2

Fenoxibenzamina, Prazosin, Terazosin, Doxazosin, Trimazosin, Indoramin, Tamsulozin, Alfuzosin

Question 3

Blocante selective alfa2

Answer 3

Yohimbina, Tolazoline, Rauwolscina

Question 4

Fentolamina

-mecanism

Answer 4

• antagonist alfa1,2 5HT2

- agonist M H1 H2

Question 5

Fentaolamina

-efecte

Answer 5

• vasodilatatie
• inotrop + si cresterea debitului cardiac
• efect prokinetic si contractie bronsica
• stimularea secretiei acide gastrice

Question 6

Fentolamina

• reactii adverse
• contraindicatii

Answer 6

• tahicardie, tahiaritmii, hTA ortostatica, dureri abdominale, varsaturi, diaree, reactii fibrotice locale ( in administrare intrapeniana de luna durata)
• ulcer GD, hipovolemie

Question 7

Fentolamina

-indicatii

Answer 7

• Feocromocitom
• flebite/tromboflebite
• sindrom Raynaud
• IC acuta
• soc
• disfunctii erectile

Question 8

Ergotoxina

-mecanism?

Answer 8

-antagonist partial alfa1 si 2 si 5HT2

Question 9

Ergotoxina

-efecte

Answer 9

• vasodilatatie cu hTA si bradicardie

- Dihidroergotoxina: vasodilatatie cu hipotensiune arteriala

Question 10

Ergotoxina

-indicatii

Answer 10

• adjuvant in HTA

- tulburari de irigatie cerebrala, Alzheimer

Question 11

Ergotoxina

-efecte adverse

Answer 11

• greata, varsaturi, diaree
• toxicitate endoteliala
• ergotism ( insomnie, halucinatii, cosmaruri, delir)
• nefrotoxicitate

Question 12

Ergotoxina

-contraindicatii

Answer 12

• psihoze endogene
• sarcina, alaptare
• hTA, bradicardie
• insuf hepatica/renala

Question 13

Fenoxibenzamina

-mecanism

Answer 13

• antagonist alfa1 si in masura f redusa alfa2
• blocant 5HT2, H1, M
• creste eliberarea si inhiba recaptarea de NA
• blocheaza transportul tubular renal al bazelor organice

Question 14

Fenoxibenzamina

-efecte

Answer 14

alfa1- scade TA cu hTA ortostatica, scaderea rezistente perf, iar reflex cresc frecventa si debitul

Question 15

Fenoxibenzamina

-indicatii

Answer 15

• feocromocitom

- flebite/tromboflebite, degeraturi, arteriopatii obstructive, sdr Raynaud

Question 16

Fenoxibenzamina

-reactii adverse

Answer 16

• hTA ortostatica, palpitatii, dureri anginoase, tahicardie, aritmii
• mioza, congestia mucoasei nazale, uscaciunea gurii, inhibarea ejacularii, greata, varsaturi
• sedare, oboseala, pierderea perceptiei timpului

Question 17

Fenoxibenzamina

-contraindicatii

Answer 17

-hipovolemie, insuf coronariana, ulcer GD, hiperplazie benigna de prostata, glaucom

Question 18

Alfuzosin si Tamsulosin, unde actioneaza?

Answer 18

alfa1 de la nivelul vaselor prostatei.

Tamsulosin e eficient la nivelul ureterelor ( producand relaxare)

Question 19

Restul alfa1-blocantelor selective

-efecte?

Answer 19

relaxarea musculaturii netede vasculare, scade TA

Question 20

Prazosin

-indicatie

Answer 20

-tratament de fond al HTA esentiale

Question 21

Terazosin, Doxazosin si Indoramin

Answer 21

tratament de fond al HTA si hiperplazia benigna de prostata

Question 22

Restul alfa1-blocantelor selective

-efecte adverse?

Answer 22

hipotensiune posturala

Question 23

Yohimbina

-indicatii

Answer 23

-analgezic in neuropatii diabetice, diabet tip 2

Question 24

Tolazoline

-indicatii

Answer 24

• alternativa in af vasospastice perif, sdr Raynaud

- HTA pulmonara cu sdr de detresa respiratorie la nn

Question 25

Urapidil

-mecanism

Answer 25

• antagonist alfa1-post
• agonist alfa2-pre
• agonist 5HT2A

Question 26

Urapidil

• efecte
• indicatie

Answer 26

• scade TA, anxiolitic

- tratamentul HTA