Cuntaneous Fungal Infections Flashcards

1
Q

objectives of self treatment of fungal infections

A

provide symptomatic relief
eradicate existin infection
prevent future recurrent infections
refer if infection widespread, systemic, recurrent, or persistent

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2
Q

activity of clotrimazole or miconazole what they are used for

A

fungistatic with broad spectrum of activity to treat dermatophyte and yeast infections

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3
Q

application of clotrimazole or miconazole

A

thin layer morning and evening

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4
Q

adverse effects of clot and micon

A

local skin irritation

hypersensitivity

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5
Q

preparations of imadazole or azoles available in canada

A

clotrimazole- cream

miconazole- cream, spray, powder

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6
Q

activity of tolnaftate and uses

A

narrow spectrum antifungal

only for dermatophyte infectiosn

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7
Q

application of tolnaftate

A

apply mornign and evenign

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8
Q

adverse effects of tolnaftate

A

local skin irritation

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9
Q

activity and uses of undecylenic acid

A

unknown

used for dermatophyte infections

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10
Q

application adn adverse effects of undecylenic acid

A

twice daily

itching, burning, stinging

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11
Q

activity of nystatin and uses

A

fungistatic or cidal

only for candidal infections

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12
Q

application and adverse effects of nystatin

A

2-3 times daily

rarely irritation

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13
Q

activity of ciclopirox

A

antimycotic agent

effective against dermatophytes, yeast, and some bacteria

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14
Q

application and adverse effects of topical ciclopirox

A

itch, burn, red

apply twice daily for 4 weeks

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15
Q

time of effects for topical ciclopirox

A

first week relief of itchign and other symptoms

reevalute if not improvement after 2 weeks

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16
Q

two types of ciclopirox

A

loprox- 1%cream/lotion

stieprox 1.5% shampoo 2-3 times per week for seborrheic dermatitis

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17
Q

activity of terbinafine

A

fungicidal to dermatophytes

fungistatic to candida

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18
Q

application adn adverse effects of topical terbinafine

A

once daily for one week

itch, burn, rash, dryness

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19
Q

uses of oral terbinafine

A

fungal nail infections

severe tinea skin infections failed with topical

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20
Q

adverse effects of oral terbinafine

A

interfere with cytp450 so hepatic failure, gi disturbances, rash, headache

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21
Q

ketaconazole activity

A

broad spectrum

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22
Q

oral ketoconazole adverse effects

A

fatal liver toxicity so only for life threatening infections

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23
Q

why are dermatophytes restricted to scalp, nails, and superficial skin

A

requires keratin for growth/proliferation

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24
Q

how are dermatophytes spread

A

contact with infected person, soil, animal, indirectly from fomites

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25
Q

most common dermatophytes in skin infection

A

trichophyton
microsporum
epidermophyton

26
Q

risk factors of tinea corporis

A

children in daycare/school
exposure to contaminated soils, peoples, animals
warm moist environment
shared towels or clothing

27
Q

signs and symptoms of tinea corporis

A
oval ring
red scaly patches 
reddened edges with sharp margins 
inner area clear
sometimes itching
28
Q

when to refer tinea cirporis

A

younger than 2
immunocomprimised
large part of body
…… reading

29
Q

treatment of tinea corporis and cruris

A

imidaxole twice daily for 4 weeks

apply to normal skin 2 cm around infected to prevent spread

30
Q

what areas are affected by tinea cruris

A

bilateral thighs
inguinal folds
butt
anal cleft

31
Q

risk factors for tinea cruris

A
wam and humid
multiple layers of clothing 
immunicompromised 
obesity 
men
32
Q

sign and symptoms of tinea cruris

A
well marginated red half moon plaque
small vesicles 
itchy 
bright red lesion 
chronic more hyperpigmented
33
Q

when do you refer tinea cruris

A

reading…..

34
Q

risk factors for tinea pedis

A
hot and damp 
occlusive footwear
public bathing facilities
high impact sports
sharing footwear
prolonged steroid application 
sweat
35
Q

signs of tinea pedis

A
toe webs 
interdigital maceration 
fissuring and scaling 
itching or stinging 
malodour
36
Q

refer tinea pedis

A

risk of delayed wound healing
less than 12
lesion inflamed oozing painful - may be bacterial
toenail affected

37
Q

chronic interdigital tinea pedis

A

fissures scaling maceration

between 3rd/4th or 4/5 toes

38
Q

vesicular type

A

itchy vesicles on instep of feet

39
Q

moccasin tinea pedis

A

off white scaling

red lesions on soles and side of feet

40
Q

acute ulcerative tinea pedis

A

macerated weepy lesions on soles of feet

41
Q

non pharms for tinea pedis

A

proper footcare/hygiene
avoid occlusive footweat
changes to dry socks
dry between toes bid and affter showering

42
Q

products pharmacists can prescribe for tinea pedis

A

topical ciclopirox twice daily for 4 weeks

topical terbinafine once daily for a week

43
Q

why is important to promptly treat tinea pedis

A

prevent development of tinea unguium or infections of toenails

44
Q

how do you treat onychomycosis

A
oral terbinafine 
tonail 12-16 weeks 
fingernail 6 weeks 
risk of liver injury so closely monitored 
ciclopirox nail lacquer takes 48 weeks
45
Q

tinea capitis

A

hair follicles
visible black dots
often in children

46
Q

tinea manuum

A

one hand two feet

47
Q

tinea unguium

A

nails brittle opaque yellow thick

48
Q

tinea incognito

A

suppresion of inflammatory response

49
Q

cause of pityriasis versicolor

A

infection of stratum corneum by malassezia

50
Q

highest risk of pityriassis versicolor

A

tropical environments

adolescents and young adults

51
Q

signs and symptoms of pityriassi versicolor

A

change in cutaneous pigementation- hyper/hypopigmented
lesions on back, chest, upper arms, coalesce to for large patches
fine scale present
cosmetic issue no itching

52
Q

piityriasis versicolor treatment

A

selenium sulfide 2.5% shampoo- apply 10 min and wash off once daily for 1-2 weeks
topical azole cream bid for 2 week
ketaconazole 2% shampoo- leave on for 5 minutes and wash off one time

53
Q

risk factors of candida intertrigo

A
diabetes mellitus 
immunosuppression
tropical environment 
poor hygiene 
psoriasis 
contact dermatitis
obesity 
hands in water lots 
overuse of cornstarch
54
Q

areas that can be affected by candida intertrigo

A
groin 
armpit
gluteal region 
under breasts
skin folds
hand
55
Q

signs of candid intertrigo

A

bright red
moist skin surface
scaling border and satellit papules

56
Q

when to refer candida intertrigo

A
unsuccessful treatment 
worsens 
unknown cause
extensively seriouslt inflamed 
systemic or recurrent 
secondary bacterial infection - discharge
immunocompromised 
under 2
57
Q

treatment of cutaneous candidiasis

A

keep dry with non medicated powder
imidazole or nystatin bid 2-3 weeks
sever combinaton of topical antifungal and topical corticosteroid

58
Q

tea tree oil as complimentary treatment

A

must be used bid for 6 months and not guaranteed

59
Q

which products can be used in pregnancy/breast feeding

A

clotrimazole
miconazole
nystatin

60
Q

general non pharms

A

use separate wash cloth/towel for area
hair dryer to dry area towel cant
socks on before underwear
launder contaminated towel and clothing separate in hot water
cleanse skin daily with soap and water and pat dry
avoid clothing that keep skin wet - wool
allow shoes to dry before using again
protective footwear in public showers and pools

61
Q

how long should treatment continue and why

A

1-2 weeks after symptoms resolution to ensure full eradication and prevent relapse

62
Q

monitoring parameters

A

relief of symptoms in 1-2 weeks
monitor daily for infection
no improvement or worsens refer
lesions should resolve within treatment timeframe