Critical Care/ER Flashcards
Malignant hyperthermia symptoms and genetics
- Defect in skeletal muscle calcium homeostasis
- Prolonged opening of ryanodine receptor leads to an excess of cytosolic calcium and prolonged muscle contraction
- Increased oxygen consumption –> lactic acidosis, hyperthermia, hypoxia, hypercarbia
- TX: DANTROLENE
Causes of malignant hyperthermia
Succinylcholine, inhaled anesthetics (halothane, isoflurane, desflurane)
Signs of bad prognosis for drowning
- Submersion > 25 minutes
- > 25 minutes of CPR at the scene
- Apnea or coma at admission
- Need for cardiac meds to establish perfusing rhythm
- Initial arterial pH of < 7.1
Flail chest symptoms and treatment
- Paradoxical chest wall movements
- 2 or more rib fractures in 2 or more locations
- Tx: Chest tube if respiratory distress
Pediatric CPR rules
- 1/3 to 1/2 of the anteroposterior depth of the chest
- Rate of 100/minute with complete chest recoil
- One rescuer: 30 compressions to 2 ventilations
- Two rescuer: 15 compressions to 2 ventilations
- If you have an airway: ventilation should be 1 breath every 6 seconds and CPR continuously at 100/minute
Indication for IV antibiotics in burn patients
- Change in appearance of the wound including new discoloration is most suggestive of an infection
- Major infections: wound infections, pneumonia, bloostream infections, UTIs
Causes of right shift of Hgb-dissociation curve
CADET C: Increased CO2 A: Acidosis D: DPG E: Exercise T: Temperature
- Right shift means oxygen is extracted easier at the tissue level (tissues need more oxygen)
Pressor for cold shock
Epinephrine (beta activity)
Pressor for warm shock
Norepinephrine (alpha activity)
Order for treatment of shock
- Fluid boluses (60/kg) + antibiotics
- Norepinephrine
- Epinephrine
- Vasopressin
- Steroids
Vitals in neurogenic shock
Hypotension and bradycardia
Treatment of anaphylactic shock
Epinephrine
Steroids
Anti-histamines
Brain death criteria
- Known and irreveresible cause of coma
- Absence of hypotension, hypothermia, metabolic abnormalities, sedating effect of medication
- Two brain death exams by different physicians done 12-24 hours apart (must have absence of brainstem reflexes including reflex to breathe)
- No ancillary studies are necessary
Requirement for organ donation
EITHER cardiac OR brain death
Brain death exam cranial nerves
- Pupillary (fixed/dilated): CN II and III
- Corneal reflex: CN V and VII
- Vestibulo-occular: CN VI and VIII (Normal cold opposite warm same: COWS)
- Occulocephalic (Doll’s eyes): CN III, IV, VI, VIII
- Tracheal (Cough/gag): CN IX