Corynebacteria

Question 1

Corynebacterium is gram _____ with a _____ shape and ______ arrangements

Answer 1

gram positive, pleomorphic rods with Palisade arrangements.

Question 2

Corynebacterium contains _____ bacteria which carries virulence genes

Answer 2

contains lysogenic bacteriophage

Question 3

Corynebacterium causes what type of infections?

Answer 3

Respiratory infection and also skin infections.

Question 4

Complications of Corynebacterium includes what?

Answer 4

throat swelling, constriction of airway (pseudomembrane).

Question 5

Diptheria is caused by what?

Answer 5

Corynebacterium diptheriae

Question 6

Death caused by Corynebacterium is _____% of respiratory cases

Answer 6

5-10% of respiratory cases

Question 7

How common is Corynebacterium diptheriae?

Answer 7

very rare now; about 0.001 cases per 100,000.

Question 8

How is Corynebacterium diptheriae spread?

Answer 8

direct physical contact of breathing the aerosolized secretions of infecte individuals.

Question 9

Is there an endemic of Corynebacterium?

Answer 9

yes in developing countries with low vaccination

Question 10

Prior to vaccinations in the 1920’s how many cases of corynebacterium diptheriae were there?

Answer 10

100-200 cases per 100,000 (mainly in children)

Question 11

What is the main virulence factor of corynebactrium?

Answer 11

AB type toxin is main virulence factor.

Question 12

What induces the toxin production of corynebacterium

Answer 12

Low iron

Question 13

Toxin AB can cause what?

Answer 13

myocarditis, polyneuritis (affects the peripheral nerves)

Question 14

What is used for treatment of Corynebacterium?

Answer 14

antitoxin

Question 15

What is the vaccine for corynebacterium?

Answer 15

DPT

Question 16

What is the test used for the diagnosis of Corynebacterium?

Answer 16

Elek test

Question 17

A fragment of toxin causes ____ and does what?

Answer 17

causes ADP- ribosylation in Elongation factor 2 dipthamide and halts the protein synthesis of host cell.