corticosteroids and anabolic steroids Flashcards
what is steroids ?
organic compounds characterised by a specific molecular structure consist of 4 interconnected carbon rings ( man made hormones )
steroids can be categorised into its function.
- corticosteroids ( adrenal gland )
- anabolic steroid ( testes )
what types of steroids in body ?
- anabolic
- corticosteroids
- sex hormones
- vitamin D
- cholesterol
what is function and medical use of corticosteroids?
function : reducing inflammation and modulate immune response
medical use : reduce inflammation and suppress immune response in autoimmune conditions
what is properties of corticosteroids
- glucocorticoid
regulate inflammation and immune response - mineralocorticoids
regulate electrolyte and fluid balance
why inflammation occur ?
body initiates in response to harmful stimuli such as pathogen , damage cell or irritants
what is symptoms of inflammation?
- redness
- heat
- swelling
- pain
what main role of inflammation?
as body defense mechanisms that help to protect and heal tissue
state acute inflammation
- allergic reaction
- infection
- burns
- trauma injury
- cuts , wounds
- frostbite
state chronic inflammation
- cardiovascular disease
- rheumatoid disease
- neurological disease
- lupus
- autoimmune diseases
example of corticosteroids based on formulations and indications
oral
asthma / crohn diseases/ allergy / MS / cancers
- prednisolone
- hydrocortisone ( low potency in creams )
- dexamethasone
- methylprednisolone
injections
joint inflammation , RA
- prednisolone
-hydrocortisone
-dexametahasone
- fludrocortisone
- methylprednisolone
- triamcinolone
topical
nasal sprays ( allergic rhinitis)
- budesonide
- beclomethasone
- mometasone
- fluticasone
eye / ear drop ( swelling and inflammation)
- betamethasone ( high potency in cream )
- hydrocortisone
- dexamethasone
what is the side effect of corticosteroids in systemic ?
- cushing syndrome
- GI irritant
- indigestion
- heartburn
- weight gain
- difficulty sleeping
- diabetes
- osteoporosis
- hypertension
- glaucoma and cataracts
- mental health
what is side effects of corticosteroids when applied to skin
- thinning skin
- permanent stretchmarks
- allergic contact dermatitis
- acne
- hair growth at site of application
in eyes or ear
- dryness
- irritation
what is anabolic steroids?
synthetic substances that mimic effects of male sex hormone testosterone
what is function of anabolic steroids?
promotes tissue and muscle growth and promote development of male sexual characteristics
for medical use
treat conditions cause muscle wasting or severe weight loss due to certain diseases
state example drug of anabolic steroid
- testosterone
- nandrolone
- stanozolol
- oxandrolone
- methandrostenolone
- trenbolone
- boldenone
- methenolone
what is properties of anabolic and androgenic ?
anabolic : promotion of tissue and muscle growth and maintains bone density
effect
- increased muscle growth and strength
- enhanced recovery after physical exertion
- reduce fatigue
androgenic : development and maintenance of make characteristic
effect
- deepening of voice
- facial and body hair growth
- increased libido
who can misuse of anabolic steroids?
- bodybuilder who are involved in competitive sport
-young people who are insecure with their body image and want to look muscular
