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4th Semester > CORE > Flashcards

CORE Flashcards

1
Q

Who r the only ppl that call core

A

Nurses

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2
Q

Who isn’t eligible for organ donation

A

Ppl who already died

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3
Q

What are transplantable organs

A 
Heart 
Liver 
Pancreas 
Lungs 
Kidneys 
Small bowel
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4
Q

CMO

A

Comfort measures only

If the order exists, before it is implemented CORE must be called

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5
Q

HLA

A

Human leukocyte antigen

Mist match to be suitable for organ donation

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6
Q

Describe the hyperacute rejection

A

Involves the humoral response
It is destructive and immediate it occurs in minutes to hours
It always results in graft destruction

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7
Q

What is early accelerated rejection

A

It involves the humoral response
It occurs within hours to days of transplant
Not reversible

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8
Q

What is acute rejection

A

It is usually T cell mediated
It occurs days to months after transplant
It is reversible

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9
Q

What is chronic rejection

A

Usually involves the humoral response
Usually occurs over a year
It is not reversible, will lead to allograft loss
Most difficult to dx

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10
Q

Antimetabolites

A

Immuran
Cellcept
( used with calcineurin inhibitor)

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11
Q

What are side effects of anti metabolites

A

Bone marrow suppression
Rash
Alopecia
GI effects with cellcept

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12
Q

Name calcineurin inhibitors

A

Cyclosporine
Sirolimus
Tacrolimua

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13
Q

What are side effects of calcineurin inhibitors

A

Nephro and hepatotoxic, neurotoxic

Hyperglycemia

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14
Q

Name corticosteroids

A

Prednisone
Methylprednisolone
Dexamethosone

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15
Q

What are side effects of corticosteroids

A 
Cushing syndrome 
Hyperglycemia 
GI bleed 
HTN
OSTEOPOROSIS
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16
Q

What is brain death

A

Brain death is determined by neurological criteria

17
Q

What is cardiac death

A

Cardiac death is defined as ASYSTOLE

18
Q

What is the general criteria for tissue donation

A 
No limit 
Tissue removal within 24 Hrs of death 
No Hx of extracranial malignancies 
No Hx do autoimmune disease 
No Hx of transmissible bacterial, viral, fungal diseases or infections 
No Hx of bacteremia or viremia
19
Q

Hyperacute rejection

A

Most destructive
Immediate in minutes to hours
Always results in graft destruction
Humoral response

20
Q

Early accelerated rejection

A

NOT REVERSIBLE

occurs within hours to days of transplant

21
Q

Acute rejection

A

Usually T cell mediated
Occurs days to months after transplant
REVERSIBLE

22
Q

Chronic rejection

A 
Usually humoral response 
Insidious 
Usually occurs over a year 
NOT REVERSIBLE, LEADS TO ALLOGRAFT LOSS
MOST DIFFICULY TO DIAGNOSE
23
Q

Give an example of a sign of a liver transplant rejection

A

Elevated LFTs

24
Q

Give an example of a sign of a small bowel rejection

A

Watery, bloody diarrhea

25
Q

Give an example of a sign of kidney rejection

A

Elevated bun and creatinine

26
Q

Give an example of a sign of a heart transplant rejection

A

SOB

FLUID RETENTION

27
Q

What is induction therapy

A

Medications administered prior to transplant and used when the risk of rejection is higher

28
Q

Name anti metabolite drugs

A

Immuran
Cellcept
* used with calcineurin inhibitors

29
Q

What are side effects of antimetabolite drugs

A

Bone marrow depression
Rash
Alopecia
GI effects with cellcept

30
Q

Name calcineurin inhibitor drugs

A

Cyclosporin
Sirolimus
Tacrolimus

31
Q

What are the side effects of calcineurin inhibitors

A

Nephro and hepatotoxic
Neurotoxic
Hyperglycemia

32
Q

Name corticosteroid drugs

A

Prednisone
Methylprednisone
Dexamethosone

33
Q

What are side effects of glucocorticoid drugs

A 
Cushing's syndrome 
Hyperglycemia 
GI BLEED 
HTN 
OSTEOPOROSIS
34
Q

What are 3 traits the nurse must have of the dying patient

A

Compassion
Comfort
Communication

35
Q

What is imminent death defined as

A

In the ICU, it is defined as death perceived within 1 hour

36
Q

What is the salad bowel society

A

Your beliefs are not shared by anyone

37
Q

What are the cardinal findings of Brain death

A

Normothermic
Deep coma
Absence of brain stem reflexes
Apnea

38
Q

What is confirmatory testing of brain death

A

Cerebral angiogram
EEG
brain scan
Transcranial Doppler

4th Semester (18 decks)

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