copper Flashcards
where are the highest concentrations of copper found
liver, brain, heart, kidney
copper functions
required for iron transport out of the enterocyte, metabolism of superoxide, catecholamines, serotonin; synthesis of ATP and Peptide hormones; cross-linking of collagen
copper RDA
adults=900 micrograms/d
sources of copper
oysters, nuts and seeds, legumes, coca, dried fruits, meat
increase copper absorption
citric acid, acidic enviroment
decreases copper absorption
acidic reducing meds, zinc, phytate
what does molybdenum do to copper
increases the excretion of copper
who is at risk of copper deficiency
those taking antacids or zinc supplements, malabsorptive conditions, menkes syndrome
symptoms of copper deficiency
anemia, depigmentation of skin and hair, bone demineralizatoin, neutropenia (impaired immunity
TUI of copper
10mg/d
symptoms of copper toxicity
nausea, vomiting, gastric pain, liver damage (jaundice), kidney damage (little to no urine outpu)
wilson’s disease
impaired copper excretion, accumulates in brain liver kidneys and eyes. causes kayser fleischer ring around cornea
which antioxidant enzyme require both zinc and copper
superoxide dismutase
supplements of ____ decrease copper absorption while supplements of ______ increase copper excretion
zinc; molybdeum
which genetic disorder is associated with an increase in copper excretion leading to deficiency
menkes syndrome