copper Flashcards

1
Q

where are the highest concentrations of copper found

A

liver, brain, heart, kidney

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2
Q

copper functions

A

required for iron transport out of the enterocyte, metabolism of superoxide, catecholamines, serotonin; synthesis of ATP and Peptide hormones; cross-linking of collagen

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3
Q

copper RDA

A

adults=900 micrograms/d

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4
Q

sources of copper

A

oysters, nuts and seeds, legumes, coca, dried fruits, meat

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5
Q

increase copper absorption

A

citric acid, acidic enviroment

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6
Q

decreases copper absorption

A

acidic reducing meds, zinc, phytate

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7
Q

what does molybdenum do to copper

A

increases the excretion of copper

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8
Q

who is at risk of copper deficiency

A

those taking antacids or zinc supplements, malabsorptive conditions, menkes syndrome

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9
Q

symptoms of copper deficiency

A

anemia, depigmentation of skin and hair, bone demineralizatoin, neutropenia (impaired immunity

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10
Q

TUI of copper

A

10mg/d

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11
Q

symptoms of copper toxicity

A

nausea, vomiting, gastric pain, liver damage (jaundice), kidney damage (little to no urine outpu)

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12
Q

wilson’s disease

A

impaired copper excretion, accumulates in brain liver kidneys and eyes. causes kayser fleischer ring around cornea

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13
Q

which antioxidant enzyme require both zinc and copper

A

superoxide dismutase

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14
Q

supplements of ____ decrease copper absorption while supplements of ______ increase copper excretion

A

zinc; molybdeum

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15
Q

which genetic disorder is associated with an increase in copper excretion leading to deficiency

A

menkes syndrome

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