Contraception Flashcards
What is contraception?
The intentional prevention of pregnancy as a consequence of sexual intercourse
When are women most fertile during a 28 day cycle?
10-17 days
What is the combined oral contraceptive pill?
A pill containing a combination of oestrogen and progesterone
How effective is the combined oral contraceptive pill with perfect use and typical use?
Perfect Use - 99%
Typical Use - 91%
In what three ways does the combined oral contraceptive pill prevent conception?
Ovulation prevention
Cervical mucus thickening
Endometrium thinning
What is the primary mechanism in which the combined oral contraceptive pill prevents conception?
Ovulation prevention
How does the combined oral contraceptive pill prevent ovulation?
This is due to the fact that oestrogen and progesterone have a negative feedback effect on the hypothalamus and anterior pituitary and therefore they suppress the release of GnRH, LH and FSH
When LH and FSH are absent, ovulation doesn’t occur
How does cervical mucus thickening prevent conception?
This prevents sperm from reaching and thus fertilising the egg
How does a thinned endometrium prevent conception?
This reduces the chance of successful implantation of a fertilised egg
What are the two types of combined oral contraceptive pills?
Monophasic
Multiphasic
What are monophasic combined oral contraceptive pills?
They contain the same amount of hormone in each pill
What are multiphasic combined oral contraceptive pills?
They contain varying amounts of the hormones to match the normal cyclical hormonal changes more closely
What are the two dosing regimes for the combined oral contraceptive pill?
Standard
Continuous dosing
What is the standard combined oral contraceptive pill regimen?
It involves individuals taking the combined pill for 21 days with a hormone free week
Describe the mechanism behind the standard combined oral contraceptive pill regimen
The lining of the endometrium is maintained in a stable state while taking the contraceptive pill
When the pill is stopped the lining of the uterus breaks down and sheds
This leads to a withdrawal bleed
This is not classed as a menstrual period as it is not part of the natural menstrual cycle
What is the continuous dosing combined oral contraceptive pill regimen?
It involves individuals taking the combined pill for 63 days (three packs) with a hormone free week
What are the two advantages of the continuous dosing combined oral contraceptive pill regimen?
This avoids the inconvenient withdrawal bleed
It avoids individuals forgetting to restart their pill after the break
Is it safe for individuals to have sexual intercourse during the hormone free week of the combined oral contraceptive pill?
Yes - as long as they remember to start their new packet
What two investigations should be conducted prior to individuals starting the combined contraceptive pill?
Blood pressure
BMI
When do individuals start the combined oral contraceptive pill?
First day of the menstrual cycle
How long does the combined oral contraceptive pill take to offer protection?
7 days
When would additional contraception be required when starting the combined oral contraceptive pill? How long for?
If it is started after day five of the menstrual cycle
Individuals will need to take extra contraception for the first seven days of consistent pill use before they are protected from pregnancy
What advice is given to individuals when they are switching between different types of the combined oral contraceptive pill?
We advise them to finish one pack then immediately start the new pack without the pill-free period
What advice is given to individuals when switching from the progesterone only pill to the combined oral contraceptive pill?
They can switch at any time, but seven days of extra contraception is required
How often should individuals take the combined oral contraceptive pill?
Daily, with 24 hours ideally between each dose
What is regarded as a missed combined oral contraceptive pill dose?
If an individual takes the pill more than 24 hours late, which therefore means that it has been 48 hours since the last pill was taken
What advice do we give if an individual has a missed the combined oral contraceptive pill by less than 72 hours?
They should take the missed pill as soon as possible even if this means taking two pills on the same day
They are not required to use extra contraception protection if other pills before and after are taken correctly
What advice do we give if an individual has a missed the combined oral contraceptive pill by more than 72 hours?
They should take the most recent missed pill as soon as possible even if this means taking two pills on the same day
They are required to use extra contraception protection until they have taken the pill regularly for seven days straight
What advice do we give if an individual has a missed the combined oral contraceptive pill by more than 72 hours (during day one to seven of the packet)?
They are required to take emergency contraception if they have had unprotected sex
What advice do we give if an individual has a missed the combined oral contraceptive pill by more than 72 hours (during day eight to fourteen of the packet)?
They are not required to take emergency contraception if they have had unprotected sex
What advice do we give if an individual has a missed the combined oral contraceptive pill by more than 72 hours (during day fifteen to twenty one of the packet)?
They are required to take emergency contraception if they have had unprotected sex
These individuals should also miss their pill-free period
What are the five non-contraceptive benefits of the combined oral contraceptive pill?
Dysmenorrhea Relief
Premenstrual Syndrome Relief
Menorrhagia Relief
Decreased Risk of Ovarian Cysts & Cancers
Acne Treatment
Which three cancers does the combined oral contraceptive pill decrease the risk of?
Ovarian
Endometrial
Colon
What are the seven side effects of combined oral contraceptive pill?
Irregular Bleeding
Breast Tenderness
Cholestasis
Headaches
Nausea
Hypertension
Depression & Mood Changes
How long does irregular bleeding persist with the combined oral contraceptive pill? What makes this side effect more common?
The first three months
Continuous dosing or extended cycle pills
What are the five risk factors associated with the combined oral contraceptive pill?
Venous Thrombosis (DVT & PE)
Arterial Thrombosis (MI & ischaemic stroke)
Breast & Cervical Cancer
Liver Disorders
Gallbladder Disease
Due to the risk of VTE, what advice is given to patients in regards to the combined oral contraceptive pill and upcoming surgery?
They should stop the pill 4 weeks before surgery
They should restart it 2 weeks after surgery
How long after stopping the combined oral contraceptive pill does the risk of breast and cervical cancer return to normal?
10 years
What are the seven relative contraindications associated with the combined oral contraceptive pill?
Controlled Hypertension
Smoking, in individuals who are > 35 years old and smoke less than 15 cigarettes/day
BMI > 35
Thromboembolic Disease FH History, which involves first degree relatives < 45 years old
Prolonged Immobility, which is normally due to a major surgery or disability
Breast Cancer History, which can be a personal history or family history associated with the BRCA gene
Current Gallbladder Disease
What are the seven absolute contraindications associated with the combined oral contraceptive pill?
Uncontrolled Hypertension
Smoker, in individuals > 35 years old and more than 15 cigarettes/day
Migraine With Aura
Thromboembolic Disease History
Ischaemic Disease History
Breast Feeding < 6 Weeks Postpartum
Current Breast Cancer
Major Surgery, with prolonged immobilisation
Positive Antiphospholipid Antibodies (SLE)
What are the two other forms of combined oral contraception, apart from the pill?
Patch
Vaginal ring
What combined contraceptive patch is usually prescribed? How often is this changed?
EVRA
Weekly
How long does the contraceptive patch take to offer protection?
7 days
What advice should be given if patients delay in changing their patch at the end of week one or two (within 48 hours)?
It should be changed immediately, with no further precautions
What advice should be given if patients delay in changing their patch at the end of week one or two (greater than 48 hours)?
It should be changed immediately and a barrier method of contraception should be used for the next 7 days
In cases where the patient has had sexual intercourse in the last 5 days, then emergency contraception should be considered
What advice should be given if patients delay in changing their patch at the end of week three?
It should be removed as soon as possible and the new patch should be applied on the usual cycle start day for the next cycle
No additional contraception is needed
What advice should be given if patients delay in changing their patch at the end of a patch free week?
A barrier contraception method should be used for 7 days following any delay at the start of a new patch cycle
What combined vaginal ring is usually prescribed? How often is this changed?
NuvaRing
Every three weeks
How long does the combined vaginal ring take to offer protection?
7 days
Can individuals take the vaginal ring out during sexual intercourse?
The ring can be taken out for three hours every twenty-four hours for sex
What is the progesterone only pill?
A type of contraceptive pill that only contains the hormone progesteron
How effective is the progesterone only pill with perfect use and typical use?
Perfect Use - 99%
Typical Use - 91%
What are the two types of progesterone only pills?
Traditional Progesterone-Only Pill
Desogesterol-Only Pills
When is the traditional progesterone only pill classified as missed?
If it is delayed by more than three hours
When is the traditional desogesterol only pill classified as missed?
If it is delayed by more than twelve hours
What are the four mechanisms in which the traditional progesterone only pill prevents conception?
Cervical Mucus Thickening
Endometrium Thinning
Ciliary Action Reduction
Ovulation Inhibition
What is the primary mechanism in which the progestogen-only pill (excluding desogestrel) prevents conception?
Cervical Mucus Thickening
What are the three mechanisms in which the traditional desogesterol only pill prevents conception?
Endometrium Thinning
Ciliary Action Reduction
Ovulation Inhibition
How does reduced ciliary action prevent conception?
It prevents movement of the egg through the fallopian tube
How is the progesterone only pill taken?
It is taken continuously, unlike the cyclical combined pills
It is therefore taken at the same time every day without a pill-free interval
How is the progesterone only pill started?
It is started between the first and fifth day of the menstrual cycle
How long does the progesterone only pill take to offer protection?
2 days
Can the progesterone only pill be started at other times of the menstrual cycle?
Yes
However, in this instance, additional contraception is required for 48 hours
What advice is given if individuals miss a progesterone only pill?
Patients are advised to take a pill as soon as possible and continue with the next pill at the usual time even if this means taking two in 24 hours
These patients are also advised to use extra contraception for the next 48 hours of regular use
Emergency contraception is required if they have had sex since missing the pill or within 48 hours of restarting the regular pills
What happens if individuals experience episodes of vomiting or diarrhoea whilst on the progesterone only pill?
These patients are advised to treat this as a missed pill.
These patients are also advised to use extra contraception until 48 hours after the vomiting and diarrhoea settle
What are the six side effects of the progesterone only pill?
Irregular Bleeding
Decreased Libido
Mood Changes
Headache
Breast Tenderness
Acne
How long does irregular bleeding persist with the progesterone only pill?
Three months
What are the three risk factors associated with the progesterone only pill?
Breast Cancer
Ovarian Cysts
Ectopic Pregnancy
How long after stopping the progesterone only pill does the risk of breast cancer return to normal?
10 years
Why does the progesterone only pill increase the risk of an ectopic pregnancy?
It reduces ciliary action in the fallopian tubes
What is the advantage of the progesterone only pill compared to the combined oral contraceptive pill?
There are fewer contraindications
What are the three contraindications of the progesterone only pill?
Breast Cancer, however, this does not include a family history just personal history.
Liver Cancer
Enzyme Inducing Drugs, such as carbamazepine, topiramate and rifampicin increase the metabolism of progesterone and oestrogen. They therefore reduce the effectiveness of the combined oral contraceptive pill.
Do antibiotics have an effect on the progesterone only pill?
No
What is another name for the progesterone-only injection?
Depot medroxyprogesterone acetate (DMPA)
What is the dosage of the progesterone-only injection?
It is given at three-month (13 weeks) intervals
What are the two forms in which the progesterone-only injection can be given?
Intramuscular
Subcutaneous
What is contained in the progesterone-only injection?
Medroxyprogesterone acetate – which is a form of progesterone
How effective is the progesterone-only injection with perfect use and typical use?
Perfect Use - 99%
Typical Use - 94%
What is the typical use of the progesterone-only injection?
Women may forget to book in for an injection every three months
What are the three ways in which the progesterone-only injection prevents conception?
Ovulation Prevention
Cervical Mucus Thickening
Endometrium Thinning
What is the primary mechanism in which the progesterone-only injection prevents conception?
It inhibits ovulation + thickens cervical mucus
What are the two types of the progesterone-only injection?
Depo-Provera Injection
Sayana-Press Injection
How is the depo-provera injection given?
Intramuscular into the upper outer quadrant of the buttock
What dose of the depo-injection is given?
1ml
How is the sayana-press injection given?
Subcutaneous into the abdomen or thigh
These patients are able to administer themselves this injection at home
What dose of the sayana-pressinjection is given?
1ml
How is the progesterone only injection started?
It is started between the first and fifth day of the menstrual cycle
How long does the progesterone only injection take to offer protection?
7 days
Can the progesterone only injection be started after day five of the menstrual cycle?
Yes
However, in this instance, additional contraception is required for 7 days