Connective Tissue Part 1 Flashcards
What is connective tissue?
Glue and Sponge
- joins, supports, provide structure
- stores liquid, exchange nutrients
Types of embryonic connective tissue?
mesenchyme
3 Types of connective tissue?
Loose CT - nerves + blood
Dense CT - support (regular vs irregular)
Reticular CT
4 Types of specialized connective tissue?
adipose
cartilage
bone
hematopoietic tissue
8 Cells of connective tissue?
- fibroblasts (make)
- endothelial cell (line)
- pericytes (pre-endo)
- macrophages (scavenge)
- lymphocytes (immune)
- plasma cell (antibodies)
- mast cell (allergies)
- adipocytes (fat store)
3 types of fibers?
collagen
reticular fibers
elastic fibers
4 components of ground substance?
glycosaminoglycans
sulfated GAGs
proteoglycans
glycoproteins
What is collagen assembly?
collagen fibril
collagen molecule (triple helix of alpha chains)
pro-collagen (proline, glycine, lysine)
Synthesis of collagen?
RER synthesize pre-pro-collagen
package in secretory vesicles
secrete pro-collagen
cleave registration peptides = insoluble
staggered self assembly
Collagen defects?
Scurvy = no vitamin C –> no hydroxylated proline
Ehlers-Danlos = no hydroxylysine or cleave registration peptides
What are the collagen types?
Type I – Loose/Dense CT, Bone – Fibrillar
Type II – Cartilage – Fibrillar
Type III – Reticular Fibers – Fibrillar
Type IV – Basal Lamina – Amorphous
Where are reticular fibers found and function?
lymph nodes –> lymphocytes
support and motility
What is elastin made of, appearance, stain, secreted, protein?
- Loose and Dense IR CT
- branching fibers
- no H+E stain
- fibroblasts as Proelastin
- fibrillin assembles in sheets/fibers
Synthesis of Elastin?
RER synthesize pro-elastin and fibrillin
pack and secrete components
assembly into immature elastic fibers
mature elastic bundles
Defect in elastin?
Marfan’s Syndrome
- mutate fibrillin gene
- loose elastic fiber organization
