Blood Flashcards
Ratio and components in blood?
Plasma
Erythrocytes (RBC)
Buffy Coat
- platelets + leukocytes (agranulocytes/granulocytes)
Plasma components?
water
protein (albumin, globulins, fibrinogen)
electrolytes, nitrogen substances
nutrients
blood gases
regulatory substances
What is serum?
plasma w/o clotting factors
Erythrocytes, size, shape, property, death?
- 7-8 um
- bi-concave shape (no nuclei)
- flexible –> return to shape after pressure
- 100 days in blood
Sickle cell anemia
RBC sickle shape - lack flexibility
- block passage = ischemic death of tissues
Thrombocytes, size, shape, death?
- 2-3 um
- disc shape (no nuclei)
- 8 days in blood
4 zones of a thrombocyte?
1) peripheral zone —- part of hyalomere
2) structural zone (cytoskeleton) —- part of hyalomere
3) organelle zone (granulomere, λ, α, δ)
4) membrane system
- open canalicular system (increase SA for release)
- dense tubular system (calcium store for coagulation)
2 types of granules?
Primary - lysosomes (azurophilic)
Specific - specific to function
Neutrophils, size, appearance, function, death?
- 10-15 um
- primary granules
- specific granules not visible (bacteria destruction)
- multi-lobe nucleus
- 10 hours in blood
Eosinophils, size, appearance, function, death?
- 12-17 um
- eosinophilic specific granules (crystalline core)
- bi-nucleated
- parasitic infection + immune reaction
- 8 hours in blood
Basophils, size, appearance, function, death?
- 10-12 um
- basophilic specific granules
- bi-nucleated
- respond to allergic reactions
- few hours in blood
Lymphocytes, size, appearance, function, death?
- 6-15 um
- little cytoplasm
- nucleus basophilic with heterochromatin
- immune system
- hours to years in blood
Monocytes, size, appearance, function, death?
- 12-20 um
- indented nucleus
- phagocytosis (destroy + immune)
- differentiate into macrophages
- 3 days in blood
