Blood Formation

Question 1

2 Types of bone marrow and its location?

Answer 1

Red Marrow – in trabeculae of metaphysis/epiphysis
Yellow Marrow (fat) – in diaphysis
— can be converted to red if need RBC

Question 2

Red bone marrow components?

Answer 2

sinusoid – discontinuous endothelial cells (gap)
adventitial cell – support sinusoid
(RT fibers = type III collagen)
hemopoietic compartments – maturation of cells

Question 3

Erythropoiesis series?

Answer 3

pro-erythroblast – nucleus
basophilic erythroblast – deep basophilia
polychromatophilic erythroblast – eosin patches
normoblast – dense nucleus, eosinophilic cytoplasm
reticulocyte – no nucleus, eosin w/ leftover ribosomes

Question 4

stimulate erythropoiesis?

Answer 4

decrease oxygen levels = more RBC (training)
decrease RBC levels = more RBC (blood doping)

Question 5

Granulopoiesis series?

Answer 5

neutrophilic/eosinophilic/basophilic
pro-myelocyte – round nucleus, primary granules
myelocyte – specific granules (neutral, pink, blue)
meta-myelocyte – indented nucleus
—> band form for neutrophil (horseshoe nucleus)

Question 6

Thrombopoiesis?

Answer 6

megakaryocyte
- interacts with sinusoid
- release platelets into bloodstream
demarcation channel = separate platelet + cytoplasm