Connective tissue Flashcards
True or false; non-sulfated GAGs holds a lot of water
true
What is larger sulfated GAGs or non-sulfated GAGs
non-sulfated
Which type of collagen makes up ~90% of total body collagen
type 1
True or false; collagen 1 is known for great tensile strength and stretching capabilities
false; does have great tensile strength but doesn’t stretch
What vitamin is crucial for collagen formation?
Vitamin C - not enough = scurvy
True or false; elastic which can stretch 150% of resting length decreases as we age
true
Marfan’s syndrome is an hereditary condition effecting what kind of ct?
elastic fibers
What kind of ct is the same as collagen 3
reticular
True or false; reticular fibers which typically last ~3 days are not affected by aging
true
What is the first fiber produced during wound healing
reticular
What are fibroblast typically derived from? When would they divide?
from mesenchyme cells
primarily during wound healing
What is the structural purpose of fibroblasts
produce and maintain matrix
What is the purpose of fibroblast in healing?
Produce growth factors and scar formation
True or false; fibroblast have some defensive function
true - produce cytokines and enzymes - can phagocytize is needed
What is a mature less active fibroblast? What can it produce?
fibrocyte
hyloronic acid, ground substance, reticular fibers
What possesses features of fibroblasts in smooth muscle
myofibroblasts
True or false; adipocytes function in lipid storage and produce leptin
true
True or false; plasma cells are typically found in the blood
false
What are macrophages derived from?
monocytes
Large cells with an indented or kidney bean shaped nucleus often containing residual bodies in cytoplasm best describes what?
macrophages
True or false; on top of phagocytizing macrophages act as APCs and create foreign body giant cells
true
What is a foreign body giant cell
permanent fusion of many macrophages
Mast cells - which are large cells containing cytoplasmic granules are derived from what?
a bone marrow precursor
True or false; histamine increases permeability - increases blood flow (vasodilation) and contracts smooth muscle
true
What is heparin? What is its effect?
Primary mediator of inflammation in an allergic reaction
switches off histamine by binding to it
What is an ECF? What do they do?
Eosinophil chemotactic factor
attracts eosinophils
What do eosinophils do? What attracts them?
inhibit leukotrienes - inhibit mast cell degranulation - limit the effects of histamine and leukotrienes
ECF (eosinophil chemotactic factor)
What are NCFs? What do they attract?
neutrophil chemotactic factor
attracts neutrophils
What effect does leukotriene have?
Same as histamine - but much more powerful (1000x) - will also extend and amplify histamine’s effects
