Congenital- Osteopetrosis

Question 1

Def.

Answer 1

• hereditary condition involving absence of resorption of normal primitive osteochondroid tissue
• osteoclasts may not respond to parathyroid hormone -> primitive calcified cartilage persists.

Question 2

Radiol Fx.

Answer 2

• Generalised skeletal sclerosis -> Homogenous increased density, absence of trabeculation, absence of medullary canal.
• Bone within a bone appearance or endobones.
• Flared elongated metaphyses on long bones.
• Spine see uniformly dense vertebrae, or sandwich vertebrae with dense bone adjacent to endplates and normal centra.