Complex Lipids (Deevska)

Question 1

fatty acid + sphingosine =

Answer 1

ceramide

Question 2

This is the only sphingolipid that is also a phospholipid.

Answer 2

Sphingomyelin

Question 3

What eye disease will sphingolipids likely give insight into helping in the future?

Answer 3

glaucoma, because it has to do with IOP

Question 4

____________= ceramide and phosphocholine

Answer 4

Sphingomyelin (SM) (head group)

Question 5

____________ is abundant in nerve tissue and myelin sheath in nerve tissue.

Answer 5

Sphingomyelin

Question 6

_________= palmitic acid + serine

Answer 6

Sphingosine

Question 7

________ is a precursor for sphingosine 1-phosphate.

Answer 7

Sphingosine

Question 8

_________ controls endocytosis of rhodopsin and other light sensitive EYE protein, the TRP channel. (she likes eye questions)

Answer 8

Sphingosine 1-phosphate

Question 9

___________ play a role in the regulation of cellular interactions and growth and development

Answer 9

Glycosphingolipids

Question 10

This is the source of blood group antigens, embryonic development, tumor antigens, and cell surface receptors for cholera, tetanus toxins, viruses, and microbes.

Answer 10

Antigenic (carb portion of a glycoplipid)

Question 11

___________= ceramide + sugar

Answer 11

Cerebroside

Question 12

What are the 3 most important cerebrosides?

Answer 12

Galactosylceramide
Glucosylceramide
lactosylceramide

Question 13

__________= ceramide +oligosaccharide+ NANA

Answer 13

Gangliosides (found in ganglion cells in CNS)

Question 14

__________= galactocerebroside + SO3- group

Answer 14

Sulfatides and they are found in brain and kidney

Question 15

________ synthesis begins in the ER with the condensation of Palmitoyl CoA and L-serine (which is the rate limiting step of this synthesis).

Answer 15

Sphingolipid

Question 16

Ceramide is transferred to ________(area in cell) where it is used as substrate for synthesis of ___________(SM-synthase) and ________.

Answer 16

Golgi
Sphingomyelin
Glycosphingolipids

Question 17

Sphingolipid synthesis requires _____ as a coenzyme.

Answer 17

PLP

Question 18

From the Golgi Syphingomyelin and Glycosphingolipids are distributed to all membranes and are secreted into ___________ (in liver, and gut)

Answer 18

Lipoproteins

Question 19

Lysosomal lipid storage disease is commonly called________ which are mostly autosomal recessive diseases.

Answer 19

Sphingolipidoses