Common Ocular Conditions in Horses Flashcards
What should be done with eyelid lacerations?
- Surgical repair
(lower + lateral = best)
What are masses of eyelids? Tx?
- Melanoma
- SCC of third eyelid
- Lymphoma
- Tx = removal / reconstructive surgeries
What are clinical signs of ulcerative keratitis / corneal ulcers?
- Pain
- Blepharospasm
- Epiphora
- Photophobia
What is treatment of corneal ulcers?
- Fluorescein + flush with saline to assess damage
- Superficial ulcers = heal w no complications = topical antimicrobial +/- topical atropine (no scar)
- Deeper ulcer = same for non-complicated, but longer time + scarring
What is keratomalacia? What should be done?
- Keratomalacia = melting ulcer
- Activation +/or production of proteolytic enzymes by =
-corneal epithelial cells
-Leucocytes
-Microbial organisms (Pseudomonas) - Tx = early + aggressive =
-topical Serum
-topical EDTA
-topical acetylcysteine
-topical tetracycline / doxycycline
-systemic NSAIDs (flunixin)
What is a descemetocele? What should be done?
- Ulcer extending all the way to the decemet’s membrane = fluorescein neagtive
- Tx = aggressive therapy, may need surgical tx
-conjunctival flap
What can occur with full thickness corneal laceration?
- Iris prolapse
What should be done with stromal abscesses?
- Medical therapy = AB
- Surgery = debridement / corneal grafting techniques
What causes viral keratitis? Tx?
- EHV 2
- Tx = topical idoxuridie, trifluorothymidine, aciclovir, interferon gamma, cortiosteroid
What is treatment of fungal keratitis?
- Slow to resolve
- Surgery = keratectomy +/- conjunctival flap
- Topical miconazole/itraconazole, amphoctericin B, VORICONAZOLE
What is seen with immune mediated keratopathies?
Treatment?
- Usually unilateral
- Slight ocular discomfort
- Vary from Irregular corneal surface to deep bullae formation, vascularisation + oedema
- Tx = medical = topical steroid, cyclosporine A / doxycycline
-Surgical = keratectomy, cyclosporine A implant
What is uveitis? What can it lead to?
- Inflammation of uvea (iris, ciliary body + choroid)
- Can lead to blindness if untreated
What can uveitis be secondary to?
- Eye ulcer
- Rhodococcus
- Immune mediated
- Leptospira spp
What are clinical signs of anterior uveitis?
- Pain - blepharospasm + epiphora
- Chemosis - red eye
- Constricted pupil
- Aqueous flare = milky appearance of anterior chamber
- Blood (hyphaema), pus (hypopyon), or fibrin in anterior chamber
What are clinical signs of posterior uveitis?
- Subtle
- Variable pain - often mild
- Vitritis
- Retinal changes
What is treatment of uveitis?
- Topical corticosteroid (if no ulcer)
- Topical NSAID (if ulcer)
- Topical AB
- Topical atropine (c/4h until pupil dilates)
- Systemic NSAID = Flunixin
- Surgery =
-suprachoroidal cyclosporine A implant
-Pars plana vitrectomy
-Enucleation
What are long term complications of Uveitis?
- Atrophy granula iridica
- Synechiae
- Cataracts
- Glaucoma
- Retinal pathology
- Blindness
- Phthisis bulbi
What can cause cataracts?
- Acquired / secondary cataracts =
-uveitis
-trauma
-tumour - Developmental opacities, including congenital cataracts
How would you examine the lens in horses?
- Retroillumination - light reflected from tapetum w focal light source at arm’s length (opacities appear dark)
- Direct focal illumination (transillumination) = direct beam light at 45o angle into lens (cataracts = white)
What are different types of cataracts?
- Capsular cataract
- Nuclear cataract
- Perinuclear (lamelar) cataract
- Equatorial cataract
- Sutural cataract
- Complete cataract
How are cataracts treated?
- Most do not require treatment - or treat primary cause if secondary
- Surgery in young foals (<4m/o) - phacoemulsification
What is normal intraocular pressure?
- 15-30mmHG
What are signs of glaucoma?
- Hydrophthalmos / buphthalmos
- Corneal oedema
- Corneal striae
- Lens luxation
- Blindness
How is Glaucoma diagnosed?
- Signs
- Tonometry
- Ultrasound
What is treatment of glaucoma?
- Carbonic anhydrase inhibitors
- Beta-blockers - timolol
- Anti-inflammatories (NSAIDs +/or steroids)
- NOT prostaglandin derivatives in horses
- Surgical =
-laser destruction of ciliary body
-aqueous shunts
-enucleation - Chemical ciliary body destruction
On histology what colour are different layers of the eye?
– Neurosensory retina = cling film
– Retinal Pigmented Epithelium = black
– Tapetum = blue, green, amber…
– Choroid = red
– Sclera = white