Common Diseases Flashcards
Treatment of type 1 DM (diabetes)
1 - Insulin production is absent, 2- insulin production inadequate
Insulin replacement
exercise
healthy diet
Main complication of Type 1 Diabetes
DKA ADiabetes Ketose Acidosis. Fruity smell. Ketones in blood in urine. Glucose higher than 150. Normally 500-800.
SX of dehydration
- increased temperature, HT rate and breathing, BP goes down. Cramps, headache, tired.
60% body weight is water - Adult
40% intracellular fluid
20% extracellular fluid
Treatment of Emphysema (damaged alveola) COPD
- stopsmoking
- inhaled bronchodialators (B agonist - albuterol - short acting)
- Corticosteroids - inhaled form
- Supplement oxygen
- Antibiotics if theres infection
Sign of breast cancer via nipple
Thickening of nipple and loss of elasticity
Peripheral Artery Disease
Blocks artery and muscle below starts to die:
1. Pain
2. Intermittent claudication, pulse present, ankle soreness
PAD - artery - central area
PVD- vein - limbs
3.
Hypoglycemia symptoms
He IS TIRED He - Headache IS - Irritabale/Sweating T- Tachycardia I- irritabaility R - restless E - excessive hunger D - Dizzy
Buerger’s (small - medium vasculitis) disease is strongly associated with
Smoking tobacco
Vasculitis is divided by the size of the vessel
giant cell arthritis can cause same side blindeness
(also known as thromboangiitis obliterans) affects blood vessels in the body, most commonly in the arms and legs. Blood vessels swell, which can prevent blood flow, causing clots to form. This can lead to pain, tissue damage, and even gangrene
Acute Pancreatitis
Acute pancreatitis is a condition where the pancreas becomes inflamed (swollen) over a short period of time. The pancreas is a small organ, located behind the stomach, that helps with digestion.
GET SMASHED
Gall stone
Ethanol
Trauma
Steroid Mumps autoimmune scorpion bite hyperlipedemia ERCP Drugs
Risk for breast Cancer
longer exposure to estrogen increases rx:
Early Menarche (mestruation)
Late menopause
Pregnancy after 35 - late pregnancy increase rx
Nulliparity - never pregnant
Paget Disease of nipple
Red, scaling, flaking, bloody discharge, itching
<1% of breast cancer
Requires needle biopsy
Most commonly ignored early warning signs of lung cancer
persistent cough
other signs include coughing blood, weight loss/weak, clubbing of finger nails - chronic hypoxia
Hepatitis
Hep B - lives at least 7 days -
AB has vaccine
Hep C - 3 weeks
CDE - no vaccine
Earliest signs of hypertension
Headache, vertigo, tinnitus, fainting, light heaaded (LV yang rising) spontaneous nosebleeds (can be asymtommatic
Diabetes Insipidus
pituitary gland sends ADH to KD - So there is a lot of urine (diluted urine)
Central DI - deficiency of ADH (vasaopressin)
Nephrogenic DI - KD or nephron dysfunction
Vasopressin - contracts blood vessel , retain water in body (ADH - antidiuretic hormone)
Degrees of burns
Superficial - 1st degree
Blister- 2nd degree
No pain - 3rd degree
Burns muscle/fascia - 4th degree
Pink eye
Viral conjunctivitis - no treatment
- Allergic conjunctivits - vasoconstrictor
- Bacteril conjunctivitis - antibiotics
- Chemical conjunctivitis - irrigation (Morgan lens - irrigation system)
Grade 1,2,3 Hypertension
I - 140-159/90-99
II - 160-179/10-109
III - <180/<110
differences between Crohn’s and Ulcerative colitis
Crohn’s disease has discontinuous lesions, anywhere in GI
Ulcerative Colitis - continuous and always in rectum
Lower GI bleeding
Diverticulosis
Mallory-weiss syndrome - excessive vomiting (upper GI bleed)
Varices - portal hypertension (upper GI bleed)
usually present with Lower GI bleed and also can be present with severe upper GI bleed
Melena - bloody, dark, tarry stool - Lower GI & sometimes upper GI
Others:
Hematochezia - bloody, bright stool - Lower GI
Hematemesis - vomiting blood (upper GI)
Hematuria - blood in urine
2 Aspects of Cirrhosis
- Liver cell dysfunction: Spider angiomata (spider veins), palmar erythema (red hands), gynecomastia (male has F breasts), enlarged liver, ascites ( fluid in the peritoneal cavity), jaundice
- Portal hypertension (backflow) - splenomegaly, esophageal varices (enlarged esophageal veins), caput medusa - vein engorgement in abdomen
increases Homocysteine and increases MMA
Homocystein and MM (Methymalonic Acid)
- Folate deficiency- High homocysteine, low MMA
- B12 deficiency (related to pernicious anemia, Also related to neuropathy) - High Homocysteine and high MMA
Both microcytic anemia - hyper-segmented neutrophil
Tumor markers for Ovarian Cancer
CA-125
Tumor marker for pancreatic cancer
C-19-9
Tumor marker for GI Cancer (esp colon)
CEA
Tumor marker for Liver Cancer, yolk sac (testiculara)
AFP
Tumor marker for prostate cancer
PSA
Due to mutation of CFTR gene
Cystic Fibrosis - Mucous in lung, difficulty breathting
Cystic fibrosis transmembrane conductance regulator
Genetic disorder
differences between Crohn’s and Ulcerative colitis
Crohn’s disease has discontinuous lesions, anywhere in GI
Ulcerative Colitis - continuous and always in rectum
<p>Test for urolithiasis (kidney stones)</p>
<p>Best test is renal CT - have to do before surgery</p>
<p>95% can be seen in x-ray</p>
<p>99% see in CT Scan but much more radiation</p>
<p>Mostly formed in kidney but can travel to ureter, bladder or urethra</p>
<p>Dopamin deficiency causes which Disease?</p>
<p>Parkinson's</p>
<p>Levodopa + carbidopa (prevents metabolism oof levodopa)</p>
<p>Pertussis</p>
<p>Whooping cough</p>
<p>Treatment of fibromyalgia</p>
<p>Aerobic exercise</p>
<p>Duloxetine (cymbalta) SNRI</p>
<p>Amitriptyline (Elavin) - tricyclic antidepressants</p>
<p>Treatment for fibromyalgia</p>
<p>exercise</p>
<p>Duloxetine (ymbalta) SNRI</p>
<p>Amitriptyline (Elavin) tricyclic antidepressant</p>
Hodgkin’s disease is cancer of
Lymphoma system
Lipoma - benign tumor of adipose/fat tissue
Hepatitis Facts
Photo
Signs of stroke
BE FAST Balance Eyes Face drooping Arms weak Speech slurred Time to call 911
2 types LU carcenoma
Small cell -15% (Poor prognosis)
non- small cell - 80-85% - different types
Temporal Arteritis
Giant cell arteritis
Inflammation of large vessels - aorta, external carotid, vertebral arteries
- jaw claudication (pain while chewing)- mostly positive for temporal arteritis -
Most feared outcome: One eye (monocular) blindness (predinsone treatment for inflammation)
Risk factor - polymyalgia rheumatica -inflammatory disorder that causes pain and stiffness in shoulder/hip girdle
>50, Female
- *Temporal artery biopsy confirms dx
- ESR will be high (over 50)
treating High cholesterol
Statins are best to lower LDL
Niacin increases HDL - exercise is best
Acute Pancreatitis
Inflammation caused by the release of excessive pancreatic enzyme
I GET SMASHED
Gall Stones** (most common in acute)
Ethanol (alcohol)** (most common in chronic - also common in acute)
Trauma *
Steroid Mumps Virus Autoimmune diseases Scorpion Stings Hypertriglyceridema ERCP Drugs
Lipase and amylase increase in labs from pancreatitis
Abdominal main - mid-epigastric that radiates to back and may be relieved by sitting forward
- nausea vomit, fever
Chronic Pacreatitis Vs Acute Paancreatitis
Chronic DM (High glucose) Steatorrhea (fat in poop) Peacreataic calcification on CT scan) Alcohol #1 cause (#2 in acute) - Children - Cystic fibrosis #1 cause
Treatment for chronic: pain mgmt, angaalgesia, paancreataic enzyme, surgery,
Acute: Supportive: NPO (not by mouth - food/drink) IV fluid, antibiotic secondary
what significantly increases rx of Abdominal Aortic Aneurysm (AAA)
Smoking ( also bladder cancer)
Aortic Aneurysm - more than 50% dilation of aortic wall
Barry Aneurism - brain - most commonly associated with atherosclerosis
Sx - abdominal masa, abdominal bruit
men 65-70, history of smoking - screened for AAA
Diagnosis -
> 5.5 abdominal > 6cm thoracic - surgical repair
Symptomatic or ruptured aneurysm - surgical repair
Cellulitis
Infection of entire dermis and subcutaneous fat
Sx: red, warm, swollen, tender (inflammation), fever
Rx - diabetes, IV drug use, immune compromised, venous stasis
Treatment - antibiotics
Stasis dermatitis
fluid build up that leaves scaling, pigmetation - from chronic edema
Celliacs (Sprue)
Affects SI villi - villi atrophy, malabsorption problem
Rx to gluten
More common in Northern European ancestry. 1% population
Sx: Steatorrhea, dermatitis herpetirmitis
Treat: Gluten free diet
Aortic Dissection
Tear in the aorta in intima of a vessel that results in blood entering media
typically from hypertension
Sx- sudden tearing/ripping pain in anterior of chest in ascending dissection, inter-scapular back pain in descending dissection. Asymmetric pulses and BP.
MCV Anemia
MCV level
Microcytic - <80 fl - iron
Normocytic 80-100 fl
Macrocytic - >100 - vitamin B12 (pernicious anemia - one cause, also vegan, malabsoprition like celiac/Crohns, proton pump inhibitors) and folic acid/B9 deficiency (dietary insufficiency- main cause) (megaloblastic anemia - DNA synthesis impaired)
Parietal cells located within gastric mucosa are destroyed through autoimmune response so intrinsic factors is not produced so vitamin b12 is not absorbed without intrinsic factor (absorbed in ilium)
Treatment of type 1 DM (diabetes)
1 - Insulin production is absent, 2- insulin production inadequate
Insulin replacement
exercise
healthy diet
Addison’s disease
A disorder in which the adrenal glands don’t produce enough hormones.
Specifically, the adrenal glands produce insufficient amounts of the hormone cortisol and sometimes aldosterone, too. When the body is under stress (e.g. fighting an infection), this deficiency of cortisol can result in a life threatening Addisonian crisis characterized by low blood pressure.
Symptoms tend to be non-specific and include fatigue, nausea, darkening of the skin, and dizziness upon standing.
Treatment involves taking hormones to replace those not produced by the adrenal glands.
Hematological Disorders
(Bleeding and Coagulations)
Sickle cell
A blood disorder that can lead to hemolytic (red blood cell) anemia, autoimmune, bone marrow failure or infection
Can come from blood transfusion or medication
Sx:
Pain areas: in the joints
Pain types: can be sudden in the chest
Whole body: dizziness, fatigue, low oxygen in the body, or malaise
Urinary: inability to make concentrated or dilute urine or blood in urine
Also common: abnormal breakdown of red blood cells, delayed development, inflamed fingers or toes, pallor, shortness of breath, or yellow skin and eyes
Anemia
Lack of healthy red blood cells
fatigue, tachycardia,
dizziness, fatigue, lightheadedness, or malaise
brittle nails, headache, pallor, shortness of breath, or weakness
Pernicious Anemia
inability of the body to properly utilize vitamin B12, which is essential for the development of red blood cells. Most cases result from the lack of the gastric protein known as intrinsic factor, without which vitamin B12 cannot be absorbed.
Gastritis and autoimmune damage parietal cells so they can’t produce intrinsic factor, which binds to B12 in the ilium, which can lead to pernicious anemia.
Cure for regular Anemia
Iron
Folate deficiency (B9)
Spina bifida - neural tube defect in babies
Megaloblastic anemia
B9 and B12 (red blood cells are big)
Thrombocytopenia
Low platelets
Polycythemia
Increase in red blood cells. Risk of blood clotting
- Smoking is significant Rx factor